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Search results for: HIF-1
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The transition from HIF-1 to HIF-2 during prolonged hypoxia results from reactivation of PHDs and HIF1A mRNA instability
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Inhibition of HIV‐1 or bacterial activation of macrophages by products of HIV‐1‐resistant human cells
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Induction of Secreted Human Immunodeficiency Virus Type 1 (HIV-1) Resistance Factors in CD4-Positive T Lymphocytes by Attenuated HIV-1 Infection
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Microarray analysis of differentially expressed genes in cells resistant to HIV-1
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Monoubiquitinated Histone H1B Is Required for Antiviral Protection in CD4+T Cells Resistant to HIV-1
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Assessment of urinary cystatin C levels in HIV-1-infected patients with preserved kidney function
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Molecular basis and potential activity of HIV-1 reverse transcriptase toward trimethylamine-based compounds
PublicationReverse transcriptase (RT) inhibitors are currently used to treat human immunodeficiency virus (HIV)-1 infections. In this work, novel triethylamine derivatives were designed and studied by rigid and flexible docking and molecular dynamics (MD) approaches. An apo form of HIV-1 RT was also studied by MD simulation to analyze comparative response of protein in ligand-bound and ligand-unbound forms. Among newly designed HIV-1 RT inhibitors,...
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Francia 1, 2, 3
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Extracting functional groups of ALLINI to design derivatives of FDA‐approved drugs: Inhibition of HIV‐1 integrase
PublicationHIV‐1 integrase (IN) is crucial for integration of viral DNA into the host genome and a promising target in development of antiretroviral inhibitors. In this work, six new compounds were designed by linking the structures of two different class of HIV‐1 IN inhibitors (active site binders and allosteric IN inhibitors (ALLINIs)). Among newly designed compounds, INRAT10b was found most potent HIV‐1 IN inhibitor considering different...
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Comparative molecular dynamics study of dimeric and monomeric forms of HIV-1 protease in ligand bound and unbound state
PublicationHuman immunodeficiency virus type 1 protease (HIV-1 PR) is a viral-encoded enzyme that forms a homodimer. HIV-1 PR is essential for replication and assembly of the virus and inactivation of HIV-1 PR enzyme causes production of immature, noninfectious viral particles and thus HIV-1 PR is an attractive target in anti-AIDS drug design. In our current work, we performed molecular dynamics (MD) calculations (500 ns) for two different...
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Inhibiting Activity of HIV-1: Protease, Reverse Transcriptase and Integrase All Together by Novel Compounds Using Computational Approaches
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Interplay between Structure and Charge as a Key to Allosteric Modulation of Human 20S Proteasome by the Basic Fragment of HIV-1 Tat Protein
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Value of Perfusion-Weighted MR Imaging in the Assessment of Early Cerebral Alterations in Neurologically Asymptomatic HIV-1-Positive and HCV-Positive Patients
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Cu(II) complexes with peptides from FomA protein containing -His-Xaa-Yaa-Zaa-His and -His-His-motifs. ROS generation and DNA degradation
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Patients with obstructive sleep apnea present with chronic upregulation of serum HIF-1α protein
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Inhibiting activity of HIV-1: protease, reverse transcriptase and integrase all together by novel compounds using computational approaches (flexible and rigid docking)
PublicationAcquired immunodeficiency syndrome (AIDS), caused by human immunodeficiency virus type 1 (HIV-1) infection, is one of the most challenging diseases in recent decades. Nevertheless the shortcomings of chemical drugs such as toxicity, lack of curative effects, the search for more potent anti-HIV agents have been focused in our study. In current study, novel scaffold was designed having a benzyl and imidazole in it which are very...
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Stability of the TinF4n+1− and GenF4n+1− superhalogen anions and the acidity of the HTi F4+1 and HGe F4+1 (n = 1–3) superacids
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Risk factors for chronic kidney disease do not influence the serum levels of asymmetric dimethylarginine in HIV-1-infected patients without significant renal disease
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Phenazine - 2,6-dihydroxybenzoic acid (1/1)
PublicationOtrzymano krystaliczny kompleks fenazyny z kwasem 2,6-dihydroksybenzoesowym o stechiometrii 1:1. Badania struktury kompleksu za pomocą metod rentgenograficznych wykazały, że powiązane wiązaniami wodorowymi typu OH...N cząsteczki fenazyny układają się w stosy, które stabilizowane są poprzez oddziaływania typu π-π pierścieni aromatycznych. Cząsteczki kwasu zajmują przestrzenie kanałów tworzonych pomiędzy kolumnami pierścieni aromatycznych...
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Influence of one‐night CPAP therapy on the changes of HIF‐1α protein in OSA patients: A pilot study
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Cardiovascular risks in HIV patients
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Ekspertyza(1)
PublicationEkspertyza dotycząca podtrzymania odwołania złożonego przez firmę EAS ENVIMET POLSKA Sp. z o.o. z siedzibą w Wieliczce, ul. Park Kingi 1 32-020 Wieliczka w Krajowej Izbie Odwoławczej przy Prezesie Urzędu Zamówień Publicznych, ul. Postępu 17a 02-676 Warszawa, wobec treści ogłoszenia o zamówieniu opublikowanym dnia 20 lipca 2013r. w Dzienniku Urzędowym Unii Europejskiej pod numerem 2013/S 140-243351 oraz wobec postanowień specyfikacji...
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Jacek Tejchman prof. dr hab. inż.
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Identification of X-DING-CD4, a new member of human DING protein family that is secreted by HIV-1 resistant CD4+ T cells and has anti-viral activity
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Thermodynamic study of binary mixtures of toluene with ionic liquids, 1-butyl-1-methylpyrrolidinium bis(trifluoromethylsulfonyl)imide, 1-hexyl-1-methylpyrrolidinium bis(trifluoromethylsulfonyl)imide and 1-butylpyridinium bis(trifluoromethylsulfonyl)imide
PublicationDensities, refractive indices and viscosities at 293.15, 298.15, 303.15, 308.15 and 313.15 K of binary mixtures of toluene with 1-butyl-1-methylpyrrolidinium bis(trifluoromethylsulfonyl)imide, 1-hexyl-1-methylpyrrolidinium bis(trifluoromethylsulfonyl)imide and 1-butylpyridinium bis(trifluoromethylsulfonyl)imide have been measured over the miscible region at p = 0.1 MPa. From the experimental data, values of excess molar volume,...
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IMAGING OF PROTON BRAGG PEAKS IN LiF
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KAWIARENKA METODYCZNA 1
EventsOtwieramy cykl comiesięcznych spotkań, by rozmawiać o inspirujących książkach dotyczących metodyki szkoły wyższej przy kawie/herbacie.
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EPAS1 resistance to miRNA-based regulation contributes to prolonged expression of HIF-2 during hypoxia in human endothelial cells
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(R,R)-1-Acetyl-1'-(2,4,6-trinitrophenyl)-2,2'-bipyrrolidine
Publication(R,R)-1-Acetyl-1'-(2,4,6-trinitrophenyl)-2,2'-bipyrrolidine has been synthesized and its rentgenostructure has been determined. The structure of the title molecule, C16H19N5O7, is mainly determined by the steric effect of a bulky 2,4,6-trinitrophenyl group attached to the N atom of a pyrrolidine ring. Both pyrrolidine rings adopt an envelope conformation, with one of the methylene C atoms as the flap in each case, and the N-C-C-N...
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1+1 Protection of Overlay Distributed Computing Systems: Modeling and Optimization
PublicationW niniejszym artykule przedstawiono autorską koncepcję ochrony transmisji od krańca do krańca (ang. 1+1 protection) dla systemów przetwarzania rozproszonego (ang. distributed computing systems). Artykuł prezentuje nowatorskie rozwiązanie dedykowane systemom typu ''overlay'', w których system przetwarzania rozproszonego stanowi warstwę najwyższą w warstwowej architekturze sieci, korzystającą z usług warstwy sieci transportowej....
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Sztywne złącza (1)
PublicationWarunki posadowienia rur, problemy oddziaływań na złącza.Obciążenia złączy rurowych. Różnice między wodoszczelnością a wytrzymałością. Normowe złącze sztywne
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Witaminy. Rozdział 1
PublicationPrzedstawiono budowę chemiczną i omówiono własności witamin rozpuszczalnych w tłuszczach (wit. A, D, E, K) oraz w wodzie (wit. B1, B2, PP, B5, B6, B12, H, C, P, kwas foliowy).
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Lancet HIV
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Hip International
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HIV Nursing
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HIV MEDICINE
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Hip and Pelvis
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Magnesium(ii) 1-(1-adamantylsulfanyl)phthalocyanine – synthesis, photochemical and electrochemical properties
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The existence and gas phase acidity of the HAlnF3n+1 superacids (n=1–4)
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The hypoxia‐induced changes in miRNA‐mRNA in RNA ‐induced silencing complexes and HIF ‐2 induced miRNAs in human endothelial cells
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A 1-nS 1-V Sub-1-µW Linear CMOS OTA with Rail-to-Rail Input for Hz-Band Sensory Interfaces
PublicationThe paper presents an operational transconductance amplifier (OTA) with low transconductance (0.62–6.28 nS) and low power consumption (28–270 nW) for the low-frequency analog front-ends in biomedical sensor interfaces. The proposed OTA implements an innovative, highly linear voltage-to-current converter based on the channel-length-modulation effect, which can be rail-to-rail driven. At 1-V supply and 1-Vpp asymmetrical input driving,...
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Human hip joint lubrication for permeable cartilage
PublicationPraca przedstawia pewien model obliczeń wartości sił tarcia zapisany w ortogonalnych sferycznych i innych krzywoliniowych układach współrzędnych dla hydrodynamicznego, niesymetrycznego przepływu cieczy synowialnej o własnościach nienewtonowskich i zmiennej lepkości w szczelinie stawu biodrowego człowieka z uwzględnieniem zmian losowych. Według informacji autora tak przedstawiony model nie był do tej pory rozpatrywany w pracach...
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3D Computer Model of the Hip Joint Cartilage
PublicationThis paper presents 3D computer model of the hip joint cartilage in the ANSYS program. Model is made on the basis of anatomy and collected data on the material constants of bone and cartilage components. Analysis and comparison of biochemical model, viscoelastic and molecular mixed - aggregation serves to facilitate the creation of the next model of reality, which could be used in the design of joint prostheses. The correctness...
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Pressure and capacity in hip joint afte injury.
PublicationPraca przedstawia zarys analitycznego wyprowadzenia równania Reynoldsa do wyznaczania rozkładów wartości ciśnienia w szczelinie sferycznego stawu biodrowego człowieka po udarze w nieustalonym ruchu impulsywnym. W wyprowadzonym modelu uwzględniono lepkosprężyste właściwości cieczy synowialnej oraz stochastyczny opis chropowatości chrząstki stawowej. Numeryczne wartości ciśnienia wyznaczono w programie Mathcad 2001 przy wykorzystaniu...
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Sciences de l'éducation pour 1'ère nouvelle (Les)
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Vital and health statistics. Ser. 1: Programs and collection procedures
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Prenatal stress affects insulin-like growth factor-1 (IGF-1) level and IGF-1 receptor phosphorylation in the brain of adult rats
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The saturation of the excess electron binding energy in AlnF3n+1- (n= 1–5) anions
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Anticancer imidazoacridinone C-1311 inhibits hypoxia-inducible factor-1α (HIF-1α), vascular endothelial growth factor (VEGF) and angiogenesis
PublicationAntitumor imidazoacridinone C-1311 is a DNA-reactive topoisomerase II and FLT3 receptor tyrosine kinase inhibitor. Here, we demonstrate the mechanism of C-1311 inhibitory action on novel targets: hypoxia-inducible factor-1α (HIF-1α), vascular-endothelial growth factor (VEGF), and angiogenesis. In a cell-free system, C-1311 prevented HIF-1α binding to an oligonucleotide encompassing a canonical hypoxia-responsive element (HRE),...
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A role for accessory genes rI.-1 and rI.1 in the regulation of lysis inhibition by bacteriophage T4
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