Agnieszka Siebert
Zatrudnienie
Kontakt dla biznesu
- Lokalizacja
- Al. Zwycięstwa 27, 80-219 Gdańsk
- Telefon
- +48 58 348 62 62
- biznes@pg.edu.pl
Kontakt
- agnglowa2@student.pg.edu.pl
Wybrane publikacje
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Tuftsin-Properties and Analogs
Immunomodulation is one of the significant therapeutic strategies. It includes both stimulation or suppression of the immune system by a variety of substances called immunomodulators, designed to regulate the immune response of the organism to infections of varying etiology. An example of such a substance is tuftsin (TKPA) 3 (Fig. (1)). Tuftsin is an endogenous immunomodulator of a wide spectrum of biological activity. Tetrapeptide...
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Synthesis and antimicrobial activity of amino acid and peptide derivatives of mycophenolic acid
The series of 16 novel amino acid and peptide mycophenolic acid (MPA) derivatives was obtained as potential antibacterial agents. Coupling of MPA with respective amines was optimized with condensing reagents such as EDCI/DMAP and T3P/TEA. Amino acid analogs were received both as methyl esters and also with the free carboxylic group. The biological activity of the products was tested on five references bacterial strains: Klebsiella...
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New Analogues of Mycophenolic Acid
Mycophenolic acid (MPA) possesses antibacterial, antifungal, antiviral, immunosuppressive and anticancer properties. It is a non-competitive and reversible inhibitor of dehydrogenase inosine-5'-monophosphate (IMPDH). This compound belongs to the immunosuppressive drugs used for the prevention of both acute and chronic transplant rejection. Until now, two derivatives of MPA have been used clinically: mycophenolate mofetil (MMF,...
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