Rok 2025

• Decoding the role of large heat shock proteins in the progression of neuroinflammation‐mediated neurodegenerative disorders

  Publikacja

  • D. Sharma

  - Rok 2025

  Chronic neuroinflammation and protein aggregation are the fundamental events mainly responsible for the progression of neurodegenerative diseases (NDs). Potential neurotoxic changes in the intra‐ and extracellular environment are typical hallmarks of many NDs. Treatment of ND is challenging, as the symptoms in these patients arises when a significant numbers of neurons have already been destroyed. Heat shock proteins (HSPs)...

• Impact of Japanese Encephalitis in Adults: Risk Factors and Associated Challenges

  Publikacja

  • D. Sharma

  - Rok 2025

  Japanese encephalitis virus belongs to flavivirus and is the main cause of viral encephalitis in many countries of Southeast Asia with high fatality rate. JE directly affects the central nervous system and ultimately leads to neuronal cell death. JEV primarily affects the pediatric age group, but in the last few years, some reports have been published from different locations of the world reporting JE cases in adults. In this...

Rok 2024

• COVID-19 and Neurodegenerative Diseases: One Health Approach

  Publikacja

  • D. Sharma

  - Rok 2024

  SARS-CoV-2, the causative agent of COVID-19, was identified in late 2019 and subsequently transmitted globally. COVID-19 has caused substantial risk to public health and safety, with a marked increase in both mortality and morbidity. Due to the high transmission and multifactorial pathogenesis of SARS-CoV-2, COVID-19 patients have reported several long-term complications, including impaired pulmonary function, fatigue, neurological...

• HPLC-DAD quantification of mangiferin, antioxidant potential and essential oil composition of the leaves of five varieties of Mangifera indica L. of North India

  Publikacja

  • D. Sharma

  - Rok 2024

  Mangifera indica L. (Mango), native of tropical Asia, has enormous genetic diversity. Comparative phytochemical analysis of leaves of five varieties of Mangifera indica viz. Dashahri, Chausa, Langra, Lucknow Safeda and Gola grown in North India was carried out. Mangiferin content (using HPLC) was found to vary from 0.96 g to 3.00 g per 100 g of dry leaves. Essential oil composition (through GC-MS) showed the major components...

• Neprilysin-Mediated Amyloid Beta Clearance and Its Therapeutic Implications in Neurodegenerative Disorders

  Publikacja

  • D. Sharma

  - Rok 2024

Rok 2023

• Understanding HIV-associated neurocognitive and neurodegenerative disorders (neuroAIDS): enroute to achieve the 95-95-95 target and sustainable development goal for HIV/AIDS response

  Publikacja

  • D. Sharma

  - Rok 2023

  The world’s sustained commitment to the HIV/AIDS response and to reaching the 2030 Sustainable Development Goal (SDG) of “ending AIDS” as a public health issue is indicated by the ambitious 95-95-95 targets for all relevant populations. Neurological conditions of AIDS (neuroAIDS) are the most significant and severe central nervous system complication associated with HIV infection in which viral antigens can enter in the brain...

Rok 2022

• A Review on Pharmacological and Therapeutic Potential of Aloe barbadensis Miller

  Publikacja

  • D. Sharma

  - Rok 2022

  Aloe vera, a popular succulent perennial medicinal plant with a wide range of phytochemicals that have shown various pharmacological activities including anti-oxidant, antimicrobial, antidiabetic, wound healing promotion and so on. Acemannan, aloe-emodin, aloin, aloesin, and emodin are widely investigated active constituents that show various pharmacological activities. Thus, the purpose of this review is to highlight previous...

• Emerging role of metabolomics for biomarker discovery in obstructive sleep apnea

  Publikacja

  • D. Sharma

  - Rok 2022

  Obstructive sleep apnea (OSA) is characterized by the complete or partial blockage of the upper airway passage during sleep which causes repetitive breaks in sleep and may result in excessive daytime sleepiness. OSA has been linked to various metabolic disorders and chronic health conditions, such as obesity, diabetes, hypertension, and depression. Profiling of alterations in metabolites and their regulation in OSA has been...

Rok 2021

• Evaluation of in vitro cytoprotective and antioxidant effects of Tinospora cordifolia in cultured HepG2 cells

  Publikacja

  • D. Sharma

  - Rok 2021

  Introduction Tinospora cordifolia is a popular medicinal plant containing a variety of phytochemicals including flavonoids, alkaloids, tannins, saponins and polyphenols, which have shown various pharmacological activities. The present study is aimed at comparing the cytoprotective and antioxidant potential of aqueous, ethanolic and methanolic extracts of T. cordifolia stem, in HepG2 cells cultured in Dulbecco’s Modified Eagle...