B-cell lymphoma, NOS - Male, 50 - Cell image [3300730069481171] - Open Research Data - MOST Wiedzy

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B-cell lymphoma, NOS - Male, 50 - Cell image [3300730069481171]

Opis

This is the histopathological image of HEMATOPOIETIC AND RETICULOENDOTHELIAL SYSTEMS cell sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

The detailed information about the patient, sample, and diagnosis are as follows:

Patient:

Age: 50

Clinical description: The material was taken from the region of the left anterior superior iliac spine. The patient is undergoing a diagnosis of the lymphoproliferative process. Immunophenotyping of blood and marrow suggests marginal zone lymphoma.

Gender: Male

Diagnosis:

Classification: ICD-O_3.2

Classification code: MALIGNANT LYMPHOMAS NOS OR DIFFUSE

Diagnosis: B-cell lymphoma, NOS

Result of the histopathological examination: Trepanobioptate in two fragments of a total length of 23 mm. Cellularity is approximately 90%. The bone marrow shows infiltrates of medium to large B lymphocytes with phenotype: CD45(+), CD20(+), Bcl2(+), CD43(+/-), MUM1(+), c-myc(+/-, in about 30% of cells). Reactions with CD10, Bcl6, CD5, Cyclin D1, SOX11, Annexin A1, DBA44, Tdt, CD34, CD23 and MPO are negative. MIB1/Ki67 60%. The infiltrates described above represent about 80% of all cells. In residually preserved normal hematopoietic tissue, E: M ratio =1:2. Granulocytic lineage (MPO+) with rejuvenation. Blastic cells with CD34 expression represent approximately 1% of all cells. Red cell lineage (CD71+) depleted. Quite numerous megakaryocytes (CD61+). Focal reticulin fibers (MF-1). The microscopic picture supports the diagnosis of B-cell lymphoma of high malignancy. Together with the phenotype determined cytometrically and the clinical presentation (splenomegaly), this is most likely a progression/transformation of splenic lymphoma (SMZL).

Sample:

Material: FFPE

Collecting method: Bone marrow aspiration

Topography: HEMATOPOIETIC AND RETICULOENDOTHELIAL SYSTEMS

Organ: HEMATOPOIETIC AND RETICULOENDOTHELIAL SYSTEMS

Tissue: Bone marrow

Type of staining: positive/IHC

Staining: Not applicable

Antibody: Ki-67

Technology:

Equipment: Pannoramic 250 3DHistech

Lens: 20x

Organization:

Source: Medical University Gdańsk

Plik z danymi badawczymi

cee79838-0f99-41d6-a8f4-3300eaf09179
121.6 MB, S3 ETag , pobrań: 24
Hash pliku liczony jest ze wzoru
hexmd5(md5(part1)+md5(part2)+...)-{parts_count} gdzie pojedyncza część pliku jest wielkości 512 MB

Przykładowy skrypt do wyliczenia:
https://github.com/antespi/s3md5

Informacje szczegółowe o pliku

Licencja:
Creative Commons: by-nc-sa 4.0 otwiera się w nowej karcie
CC BY-NC-SA
Użycie niekomercyjne - Na tych samych warunkach
Dane surowe:
Dane zawarte w datasecie nie zostały w żaden sposób przetworzone.
Oprogramowanie:
CaseViewer 2.3

Informacje szczegółowe

Rok publikacji:
2022
Data zatwierdzenia:
2021-06-16
Data wytworzenia:
2021
Język danych badawczych:
angielski
Dyscypliny:
  • nauki medyczne (Dziedzina nauk medycznych i nauk o zdrowiu)
DOI:
Identyfikator DOI 10.34808/52ke-4n52 otwiera się w nowej karcie
Ethical papers:
NKBBN/421-306/2020
Weryfikacja:
Gdański Uniwersytet Medyczny

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