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Development of different methods for drugs and psychoactive substances extraction from hair samples and their identification based on HPLC-ESI-QTOF analysis
Abstrakt
Over the past decade, the use of non-controlled designer drugs and drug of abuse has rapidly increased. Hair, as a human matrix, enables detection of drugs incorporated into its structure. Studies of presence and identification of drug metabolites in human hair samples has been performed using liquid chromatography electrospray ionization quadrupole time of flight mass spectrometry (HPLC-ESI-QTOF-MS) with steady alternation of MS and MS/MS. The comparison of three analytical procedures (including decontamination and extraction steps) allowing qualitative screening of drugs present in hair samples were performed based on hair samples collected from 13 volunteers declaring exposition to several drugs. It was concluded, that all methods are suitable to extract the majority of the relevant substances from hair. In spite of this, ambiguity correlation between data known from volunteers questionnaires and data obtained from HPLC-ESI-QTOF-MS analyses has been observed and discussed - - .
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Informacje szczegółowe
- Kategoria:
- Aktywność konferencyjna
- Typ:
- publikacja w wydawnictwie zbiorowym recenzowanym (także w materiałach konferencyjnych)
- Tytuł wydania:
- W : Proceedings of the 11th International Students Conference : "Modern Analytical Chemistry" strony 1 - 6
- Język:
- angielski
- Rok wydania:
- 2015
- Opis bibliograficzny:
- Aszyk J., Kot-Wasik A.: Development of different methods for drugs and psychoactive substances extraction from hair samples and their identification based on HPLC-ESI-QTOF analysis// W : Proceedings of the 11th International Students Conference : "Modern Analytical Chemistry"/ ed. Karel Nesměrák Praga: , 2015, s.1-6
- Weryfikacja:
- Politechnika Gdańska
wyświetlono 101 razy