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Potential of Silver Nanoparticles in Overcoming the Intrinsic Resistance of Pseudomonas aeruginosa to Secondary Metabolites from Carnivorous Plants
Abstrakt
Carnivorous plants are exemplary natural sources of secondary metabolites with biological activity. However, the therapeutic antimicrobial potential of these compounds is limited due to intrinsic resistance of selected bacterial pathogens, among which Pseudomonas aeruginosa represents an extreme example. The objective of the study was to overcome the intrinsic resistance of P. aeruginosa by combining silver nanoparticles (AgNPs) with secondary metabolites from selected carnivorous plant species. We employed the broth microdilution method, the checkerboard titration technique and comprehensive phytochemical analyses to define interactions between nanoparticles and active compounds from carnivorous plants. It has been confirmed that P. aeruginosa is resistant to a broad range of secondary metabolites from carnivorous plants, i.e., naphthoquinones, flavonoids, phenolic acids (MBC = 512 µg mL−1) and only weakly sensitive to their mixtures, i.e., extracts and extracts’ fractions. However, it was shown that the antimicrobial activity of extracts and fractions with a significant level of naphthoquinone (plumbagin) was significantly enhanced by AgNPs. Our studies clearly demonstrated a crucial role of naphthoquinones in AgNPs and extract interaction, as well as depicted the potential of AgNPs to restore the bactericidal activity of naphthoquinones towards P. aeruginosa. Our findings indicate the significant potential of nanoparticles to modulate the activity of selected secondary metabolites and revisit their antimicrobial potential towards human pathogenic bacteria.
Cytowania
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6
CrossRef
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0
Web of Science
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6
Scopus
Autorzy (9)
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Marta Krychowiak-Maśnicka
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Miroslawa Krauze-Baranowska
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Sylwia Godlewska
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Zbigniew Kaczyński
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Aleksandra Bielicka-giełdoń dr
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Natalia Grzegorczyk
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Magdalena Narajczyk dr
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Aleksandra Krolicka
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Pełna treść
- Wersja publikacji
- Accepted albo Published Version
- DOI:
- Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.3390/ijms22094849
- Licencja
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otwiera się w nowej karcie
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Informacje szczegółowe
- Kategoria:
- Publikacja w czasopiśmie
- Typ:
- artykuły w czasopismach
- Opublikowano w:
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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
nr 22,
ISSN: 1661-6596 - Język:
- angielski
- Rok wydania:
- 2021
- Opis bibliograficzny:
- Krychowiak-Maśnicka M., Krauze-Baranowska M., Godlewska S., Kaczyński Z., Bielicka-Giełdoń A., Grzegorczyk N., Narajczyk M., Frackowiak J. E., Krolicka A.: Potential of Silver Nanoparticles in Overcoming the Intrinsic Resistance of Pseudomonas aeruginosa to Secondary Metabolites from Carnivorous Plants// INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES -Vol. 22,iss. 9 (2021), s.4849-
- DOI:
- Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.3390/ijms22094849
- Weryfikacja:
- Politechnika Gdańska
wyświetlono 82 razy
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