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Proteases immobilized on nanomaterials for biocatalytic, environmental and biomedical applications: Advantages and drawbacks
Abstrakt
Proteases have gained significant scientific and industrial interest due to their unique biocatalytic characteristics and broad-spectrum applications in different industries. The development of robust nanobiocatalytic systems by attaching proteases onto various nanostructured materials as fascinating and novel nanocarriers has demonstrated exceptional biocatalytic performance, substantial stability, and ease of recyclability over multiple reaction cycles under different chemical and physical conditions. Proteases immobilized on nanocarriers may be much more resistant to denaturation caused by extreme temperatures or pH values, detergents, organic solvents, and other protein denaturants than free enzymes. Immobilized proteases may present a lower inhibition. The use of non-porous materials in the immobilization prevents diffusion and steric hindrances during the binding of the substrate to the active sites of enzymes compared to immobilization onto porous materials; when using very large or solid substrates, orientation of the enzyme must always be adequate. The advantages and problems of the immobilization of proteases on nanoparticles are discussed in this review. The continuous and batch reactor operations of nanocarrier-immobilized proteases have been successfully investigated for a variety of applications in the leather, detergent, biomedical, food, and pharmaceutical industries. Information about immobilized proteases on various nanocarriers and nanomaterials has been systematically compiled here. Furthermore, different industrial applications of immobilized proteases have also been highlighted in this review.
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Autorzy (5)
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Sarmad Ahmad Qamar
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Diego Carballares
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Ángel Berenguer-Murcia
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Roberto Fernandez-Lafuente
Cytuj jako
Pełna treść
- Wersja publikacji
- Accepted albo Published Version
- DOI:
- Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.1016/j.biotechadv.2023.108304
- Licencja
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otwiera się w nowej karcie
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Informacje szczegółowe
- Kategoria:
- Publikacja w czasopiśmie
- Typ:
- artykuły w czasopismach
- Opublikowano w:
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BIOTECHNOLOGY ADVANCES
nr 70,
ISSN: 0734-9750 - Język:
- angielski
- Rok wydania:
- 2024
- Opis bibliograficzny:
- Bilal M., Qamar S. A., Carballares D., Berenguer-Murcia Á., Fernandez-Lafuente R.: Proteases immobilized on nanomaterials for biocatalytic, environmental and biomedical applications: Advantages and drawbacks// BIOTECHNOLOGY ADVANCES -Vol. 70, (2024), s.108304-
- DOI:
- Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.1016/j.biotechadv.2023.108304
- Źródła finansowania:
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- IDUB
- Weryfikacja:
- Politechnika Gdańska
wyświetlono 16 razy
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