Small regulatory bacterial RNAs regulating the envelope stress response - Publikacja - MOST Wiedzy


Small regulatory bacterial RNAs regulating the envelope stress response


Most bacteria encode a large repertoire of RNA-based regulatory mechanisms. Recent discoveries have revealed that the expression of many genes is controlled by a plethora of base-pairing noncoding small regulatory RNAs (sRNAs), regulatory RNA-binding proteins and RNA-degrading enzymes. Some of these RNA-based regulated processes respond to stress conditions and are involved in the maintenance of cellular homeostasis. They achieve it by either direct posttranscriptional repression of several mRNAs, including blocking access to ribosome and/or directing them to RNA degradation when the synthesis of their cognate proteins is unwanted, or by enhanced translation of some key stressregulated transcriptional factors. Noncoding RNAs that regulate the gene expression by binding to regulatory proteins/transcriptional factors often act negatively by sequestration, preventing target recognition. Expression of many sRNAs is positively regulated by stress-responsive sigma factors like RpoE and RpoS, and two-component systems like PhoP/Q, Cpx and Rcs. Some of these regulatory RNAs act via a feedback mechanism on their own regulators, which is best reflected by recent discoveries, concerning the regulation of cell membrane composition by sRNAs in Escherichia coli and Salmonella, which are highlighted here.


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Informacje szczegółowe

Publikacja w czasopiśmie
artykuł w czasopiśmie wyróżnionym w JCR
Opublikowano w:
BIOCHEMICAL SOCIETY TRANSACTIONS nr 45, wydanie 2, strony 417 - 425,
ISSN: 0300-5127
Rok wydania:
Opis bibliograficzny:
Klein-Raina G., Raina S.: Small regulatory bacterial RNAs regulating the envelope stress response// BIOCHEMICAL SOCIETY TRANSACTIONS. -Vol. 45, iss. 2 (2017), s.417-425
Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.1042/bst20160367
Politechnika Gdańska

wyświetlono 39 razy

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