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• Optimization of Chemical Functionalities of Indole-2-carboxamides To Improve Allosteric Parameters for the Cannabinoid Receptor 1 (CB1)

  Publikacja

  • L. Khurana
  • H. I. Ali
  • T. Olszewska
  • K. H. Ahn
  • A. Damaraju
  • D. A. Kendall
  • D. Lu

  - JOURNAL OF MEDICINAL CHEMISTRY - Rok 2014

  5-Chloro-3-ethyl-N-(4-(piperidin-1-yl)phenethyl)-1H-indole-2-carboxamide (1; ORG27569) is a prototypical allosteric modulator for the cannabinoid type 1 receptor (CB1). Here, we reveal key structural requirements of indole-2-carboxamides for allosteric modulation of CB1: a critical chain length at the C3-position, an electron withdrawing group at the C5-position, the length of the linker between the amide bond and the phenyl ring...

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• cDNA fingerprint from the hepatopancreatic glands of pond snails (Lymnaea stagnalis) exposed to benzo[a]pyrene

  Publikacja

  • M. Woźny
  • P. Kowal
  • S. Ciesielski
  • F. Maciej
  • R. Wiśniewski
  • E. Malicka
  • P. Brzuzan

  - Environmental Biotechnology - Rok 2014

  Identification of differentially expressed genes that could be potentially used as biomarkers of PAH exposure of common invertebrate animal (like freshwater snail) would be a valuable resource for investigators interested in toxicology and biomonitoring of aquatic environments. Therefore, the aim of this research was to investigate effects of waterborne benzo[a]pyrene (B[a]P) exposure on mRNA expression in the pond snail’s (Lymnaea...

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