Wyniki wyszukiwania dla: MOLECULAR CHAPERON

• A mobile loop order–disorder transition modulates the speed of chaperonin cycling

  Publikacja

  • F. Shewmaker
  • M. J. Kerner
  • M. Hayer-Hartl
  • G. Klein-Raina
  • C. Georgopoulos
  • S. J. Landry

  - PROTEIN SCIENCE - Rok 2004

  Molecular machines order and disorder polypeptides as they form and dissolve large intermolecular interfaces, but the biological significance of coupled ordering and binding has been established in few, if any, macromolecular systems. The ordering and binding of GroES co-chaperonin mobile loops accompany an ATP-dependent conformational change in the GroEL chaperonin that promotes client protein folding. Following ATP hydrolysis,...

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