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Wyniki wyszukiwania dla: PARP1

Wyniki wyszukiwania dla: PARP1

  • Biochemical, Structural Analysis, and Docking Studies of Spiropyrazoline Derivatives

    Publikacja
    • A. Adamus-Grabicka
    • M. Daśko
    • P. Hikisz
    • J. Kusz
    • M. Malecka
    • E. Budzisz

    - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES - Rok 2022

    In this study, we evaluated the antiproliferative potential, DNA damage, crystal struc‐ tures, and docking calculation of two spiropyrazoline derivatives. The main focus of the research was to evaluate the antiproliferative potential of synthesized compounds towards eight cancer cell lines. Compound I demonstrated promising antiproliferative properties, especially toward the HL60 cell line, for which IC50 was equal to 9.4 μM/L....

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