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• Electron-Induced Decomposition of 5-Bromo-4-thiouracil and 5-Bromo-4-thio-2′-deoxyuridine: The Effect of the Deoxyribose Moiety on Dissociative Electron Attachment

  Publikacja

  • F. Izadi
  • A. Szczyrba
  • M. Datta
  • O. Ciupak
  • S. Demkowicz
  • J. Rak
  • S. Denifl

  - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES - Rok 2023

  When modified uridine derivatives are incorporated into DNA, radical species may form that cause DNA damage. This category of molecules has been proposed as radiosensitizers and is currently being researched. Here, we study electron attachment to 5-bromo-4-thiouracil (BrSU), a uracil derivative, and 5-bromo-4-thio-20 -deoxyuridine (BrSdU), with an attached deoxyribose moiety via the N-glycosidic (N1-C) bond. Quadrupole mass spectrometry...

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