Wyniki wyszukiwania dla: detoxication

• Involvement of human glutathione S-transferase M1-1 in the glutathione conjugation of the antitumor unsymmetrical bisacridine derivative C-2028.

  Dane Badawcze

  open access

  • A. Potęga
  • A. Mierzejewska
  • J. Pasztelan
  • K. Kozłowska-Tylingo

  Unsymmetrical bisacridines (UAs) are a novel potent class of antitumor-active therapeutics. The aim of this study was to investigate the possible role of human glutathione S-transferase M1-1 (hGSTM1-1) in the glutathione (GSH) conjugation of a representative UA, C‑2028.

• Glutathione conjugation of the antitumor-active 1-nitroacridine derivatives compounds C-857 and C-1748 – the major role of glutathione S-transferase M1-1

  Dane Badawcze

  open access

  • A. Potęga
  • A. Mierzejewska
  • J. Pasztelan

  Objectives: C-857 and C-1748 are antitumor-active agents, monomers of unsymmetrical bisacridine derivatives. The aim of this study was to analyze their glutathione (GSH) conjugation in vitro in the presence of glutathione S-transferase (GST) M1-1.