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Wyniki wyszukiwania dla: cardiomyocyte
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Analysis of non-linear properties of cardiomyocyte cellular membranes.
PublikacjaNieliniowe właściwości błon komórkowych kardiomiocytów są dotychczas słabo poznane. W pracy zamodelowano błonę komórkową przy pomocy modelu Beelera-Reutera w modyfikacji Drouharda-Roberge. Przeprowadzono symulacje z użyciem pobudzenia napięciowego o częstotliwości 1 lub 100 kHz i wartości skutecznej 1 lub 10 mV. Prądy płynące przez błonę rozpatrywano jako odpowiedź. Stwierdzono odpowiedź na częstotliwości podstawowej oraz jej drugiej...
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Insight into heart regeneration
PublikacjaThe mammalian heart is thought to be incapable of regeneration because of the limited ability of cardiomyocytes. to proliferate. However, it has been recently shown that the neonatal murine heart is able to restore its normal function after coronary artery ligation or even partial resection. Unfortunately, this feature is lost in a few days after birth, although lower vertebrates as zebrafish or newt, retain this ability until adulthood. Therefore,...
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Insulin-like growth factor type 2 is better than insulin-like growth factor type 1 a survival marker in patients after acute decompensation of heart failure
PublikacjaIntroduction:A decreased IGF-1 has been found in heart failure (HF). There are no reports assessing IGF-2 in HF, although in vitro study has shown, that IGF-2 stimulates cardiomyocyte proliferation more than IGF-1. The study aim was to compare the IGF-1 and IGF-2 concentration depending on HF exacerbation and annual survival.Material and methods:Among 75 patients hospitalized...
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Dietary intervention with beetroot juice during doxorubicin cancer chemotherapy in vivo reduces markers of oxidative stress
PublikacjaCancer chemotherapy with doxorubicin, despite high antitumor activity and broad spectrum of this drug, is on decline due to toxic side effects. The clinical efficacy of anthracyclines have continuously prompted the search for new adjuvants to alleviate undesirable side toxicity incurred by this group of cytostatics. The recent approaches involve the application of synthetic or purified natural antioxidants in combination with doxorubicin...