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Telomerase inhibition - unfulfilled hopes in the perfect molecular target
PublikacjaTelomerase plays a pivotal role in cell proliferation, homeostasis, and neoplastic transformation, making it a promising molecular target for cancer chemotherapy. Of note, although hTERT has been explored thoroughly as a target, none of the promising molecules has been approved as a drug until now. The subject of research conducted as part of my doctoral dissertation is explaining the cellular and molecular mechanism of action...
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Fatty acids as molecular carriers in cleavable antifungal conjugates
PublikacjaConjugates composed of C2-18 fatty acid (FA) residues as a molecular carrier and 5-fluorocytosine (5-FC) as an active agent, released upon the action of intracellular esterases on the ester bond between FA and “trimethyl lock” intramolecular linker, demonstrate good in vitro activity against human pathogenic yeasts of Candida spp. The minimal inhibitory concentrations (MIC) values for the most active conjugates containing caprylic...
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Molecular Dynamics simulations of thermal conductivity of penta-graphene
PublikacjaThe thermal conductivity of penta-graphene (PG), a new two dimensional carbon allotrope and its dependence on temperature, strain, and direction are studied in this paper. The thermal conductivity of PG is investigated using a non-equilibrium molecular dynamics simulation (NEMD) with the Two Region Method by applying the optimized Tersoff interatomic potential. Our study shows that the thermal conductivity of PG (determined for...
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Changes of Conformation in Albumin with Temperature by Molecular Dynamics Simulations
PublikacjaThis work presents the analysis of the conformation of albumin in the temperature range of 300K – 312K, i.e., in the physiological range. Using molecular dynamics simulations, we calculate values of the backbone and dihedral angles for this molecule. We analyze the global dynamic properties of albumin treated as a chain. In this range of temperature, we study parameters of the molecule and the conformational entropy derived from...
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Cellular and Molecular Bioengineering
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DIAGNOSTIC MOLECULAR PATHOLOGY
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MOLECULAR BRAIN RESEARCH
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AIMS Molecular Science
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Clinical and Molecular Hepatology
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GENETICS AND MOLECULAR BIOLOGY
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Frontiers in Molecular Neuroscience
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ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
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Current Molecular Pharmacology
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Molecular Oral Microbiology
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MOLECULAR ECOLOGY NOTES
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EXPERIMENTAL AND MOLECULAR MEDICINE
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Molecular & Cellular Biomechanics
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EMBO Molecular Medicine
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GENETICS AND MOLECULAR RESEARCH
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Research in Molecular Medicine
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Clinical and Molecular Allergy
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Journal of Molecular Psychiatry
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Molecular and Cellular Pediatrics
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Journal of Molecular Signaling
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INSECT MOLECULAR BIOLOGY
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Molecular and Cellular Pharmacology
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HUMAN MOLECULAR GENETICS
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Molecular & Cellular Oncology
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Journal of Molecular Catalysis
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Molecular Therapy-Oncolytics
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Molecular and Clinical Oncology
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Algorithms for Molecular Biology
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MOLECULAR MEMBRANE BIOLOGY
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JOURNAL OF MOLECULAR NEUROSCIENCE
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JOURNAL OF MOLECULAR DIAGNOSTICS
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MOLECULAR GENETICS AND METABOLISM
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PLANT MOLECULAR BIOLOGY
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MOLECULAR REPRODUCTION AND DEVELOPMENT
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MOLECULAR & CELLULAR PROTEOMICS
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JOURNAL OF MOLECULAR ENDOCRINOLOGY
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MOLECULAR CANCER RESEARCH
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Medical Molecular Morphology
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Molecular Ecology Resources
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Molecular Diagnosis & Therapy
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MOLECULAR PHYLOGENETICS AND EVOLUTION
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