Analytical Strategies and Applications in Lipidomics

Weronika Hewelt-Belka; Agata Kot-Wasik

doi:10.1007/978-3-030-63957-0_7-1

Analytical Strategies and Applications in Lipidomics

Abstract

Lipidomics is a field of study aiming at a comprehensive analysis of a set of lipids in biological systems. This includes both quantitative and qualitative characterization of lipid profiles, comparative studies of lipidomes, and analysis of lipid-protein interactions. Lipids are structurally diversified that make their analysis a challenging task. The constant advances in analytical technologies, especially in the field of high-performance liquid chromatography and mass spectrometry, drive progress in lipid science. Commonly, lipidomics strategies are classified as targeted, untargeted, and focused. Many analytical techniques can be employed in the lipidomic study. The choice of an appropriate analytical tool for lipid analysis depends mainly on the aim of the study. In this chapter, we present an overview of the analytical techniques and data treatment used in the analysis of lipids in biological samples, with a special focus on LC-MS-based approaches. We also present the application of the lipidomic study in the comprehensive comparative analysis and discuss the limitation and advantages of the sample preparation techniques used in lipidomics.

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Authors (2)

Weronika Hewelt-Belka dr inż.
Agata Kot-Wasik prof. dr hab. inż.

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Category:: Monographic publication
Type:: rozdział, artykuł w książce - dziele zbiorowym /podręczniku w języku o zasięgu międzynarodowym
Language:: English
Publication year:: 2021
Bibliographic description:: Hewelt-Belka W., Kot-Wasik A.: Analytical Strategies and Applications in Lipidomics// Handbook of Bioanalytics/ : Springer, 2021,
DOI:: Digital Object Identifier (open in new tab) 10.1007/978-3-030-63957-0_7-1
Verified by:: Gdańsk University of Technology