Chitosan-Nanogold and Chitosan-Nanozinc Electrodeposited Coatings for Biomedical Applications

Michał Bartmański; Marcin Wekwejt; Krzysztof Urbanowicz; Aleksandra Dorota Mielewczyk-Gryń; Grzegorz Gajowiec; Anna Pałubicka; Anna Michno; Paweł Kamil Serafin; Patrycja Koszałka

doi:10.1002/jbm.b.35571

Chitosan-Nanogold and Chitosan-Nanozinc Electrodeposited Coatings for Biomedical Applications

Abstract

Bacterial infections represent a significant challenge to the success rate of both short- and long-term titanium implants.Consequently, there is a persistent need for effective strategies to prevent such infections. In this study, chitosan-based coatingsmodified with gold or zinc nanoparticles, recognized for their antibacterial properties, were electrophoretically deposited (EPD)onto the Ti13Zr13Nb alloy and thoroughly characterized. The effects of EPD voltage, surfactant use, and metallic nanoparticletype and concentration were investigated with regard to the microstructure and properties of the obtained chitosan-based coat-ings. Incorporating metallic nanoparticles into the chitosan matrix increased surface roughness (from 54 nm to even 146 nm),particularly at higher EPD voltages, resulting in a composite structure containing nanometal clusters. The addition of gold nano-particles reduced the thickness of the coatings (from 3.90 μm for the chitosan coating with Tween20–3.43 μm); zinc had no effect.Reducing the deposition voltage from 20 V to 10 V resulted in a thickness reduction of around 50% for all tested modifications.The improvement in plastic deformation resistance (indicated by the H 3/E 2 ratio) was demonstrated for gold and zinc coatingsdeposited at lower voltages (from 0.34 MPa for the chitosan coating with Tween20 to 1.00 MPa for the gold half and 1.78 MPa forthe zinc coating). A twofold increase in voltage resulted in a significant enhancement of coating adhesion—by approximately177% for gold-added coatings and 138% for zinc-added coatings. Biological responses were dependent upon the types and con-centrations of nanometals. Nanogold induced erythrocyte hemolysis, whereas nanozinc exhibited no adverse effects. Notably,gold-doped coatings demonstrated antibacterial efficacy against Staphylococcus aureus, while zinc-doped counterparts did not.Both nanometals, however, demonstrated reduced cytocompatibility at higher concentrations. Biological response tests indicatedthat 2-fold and 4-fold dilutions of the extracted medium do not show cytotoxicity for gold and zinc nanoparticles, respectively.These findings highlight the considerable extent to which coating parameters can be modified by adjusting selected EPD processparameters.

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Authors (9)

Michał Bartmański dr inż.
Marcin Wekwejt dr inż.
Krzysztof Urbanowicz
Aleksandra Dorota Mielewczyk-Gryń (formerly: Aleksandra Mielewczyk-Gryń) dr hab. inż.
Grzegorz Gajowiec dr inż.
Anna Pałubicka dr
Anna Michno dr hab.
Paweł Kamil Serafin
Patrycja Koszałka

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Articles

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artykuły w czasopismach

Published in:

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS no. 113,
ISSN: 1552-4973

Language:

English

Publication year:

2025

Bibliographic description:

Bartmański M., Wekwejt M., Urbanowicz K., Mielewczyk-Gryń A., Gajowiec G., Pałubicka A., Michno A., Serafin P. K., Koszałka P.: Chitosan-Nanogold and Chitosan-Nanozinc Electrodeposited Coatings for Biomedical Applications// JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS -,iss. 113/4 (2025), s.1-17

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