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Abstract
The efficacy of microemul-sion in dermal and transdermal delivery of active ingredients. Here, we assessed the water-in-oilmicroemulsion capacity to incorporate two natural polymers, i.e. collagen and hyaluronic acid withlow and high molecular weight. Systems were extensively characterized in terms of conductivity, phaseinversion studies, droplet diameter, polydispersity index and rheological properties. The results of thisresearch indicate that the structure and extent of water phase in microemulsions is governed by ratioand amount of surfactant mixture (sorbitan ester derivatives). However, results have also shown thatcollagen, depending upon the weight of the molecule and its surface activity, influence the droplet sizeof the microemulsions. While the hyaluronic acid, especially with high molecular weight, due to thewater-binding ability and hydrogel formation alters the rheological properties of the microemulsion,thus providing viscous consistency of the formulation.
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Details
- Category:
- Articles
- Type:
- artykuł w czasopiśmie wyróżnionym w JCR
- Published in:
-
CARBOHYDRATE POLYMERS
no. 175,
pages 347 - 354,
ISSN: 0144-8617 - Language:
- English
- Publication year:
- 2017
- Bibliographic description:
- Szumała P., Kupper S., Kłosowska-Chomiczewska I.: Collagen and hyaluronic acid hydrogel in water-in-oil microemulsion delivery systems// CARBOHYDRATE POLYMERS. -Vol. 175, (2017), s.347-354
- DOI:
- Digital Object Identifier (open in new tab) 10.1016/j.carbpol.2017.08.010
- Verified by:
- Gdańsk University of Technology
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