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Determination of Toxicological Parameters of Selected Bioactive Organic Chemicals Using the Ostracodtoxkit FTM

Abstract

Assessment of the impact of pharmaceutical residues on living organisms is very complex subject. Apart from taking into account the toxicity of individual compounds also their presence in mixtures should be taken into account. In this work, attempts were made to assess the ecotoxicity of biologically active substances (with 50 % effective concentration (EC50) values growing from fluoxetine (EC50 = 4.431 nM) >> gemfibrozil ≈ 17α-ethinylestradiol ≈ ketorolac > indomethacin > theophylline ≈ progesterone > naproxen ≈ trypsin > 2-(2,4,5-trichlorophenoxy)propionic acid > chloramphenicol > acetylsalicylic acid > ibuprofen > ketoprofen > 19-norethindrone to bezafibrate as the least toxic drug among studied ones) to the ISO standardized Ostracodtoxkit FTM bioassay. The Ostracodtoxkit FTM was proven to be very sensitive tool with respect to responding to presence of pharmaceuticals.

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Category:
Articles
Type:
artykuły w czasopismach recenzowanych i innych wydawnictwach ciągłych
Published in:
Chemistry-Didactics-Ecology-Metrology no. 23, edition 1-2, pages 113 - 126,
ISSN: 1640-9019
Language:
English
Publication year:
2018
Bibliographic description:
Kudłak B., Wieczerzak M., Namieśnik J.: Determination of Toxicological Parameters of Selected Bioactive Organic Chemicals Using the Ostracodtoxkit FTM// Chemia-Dydaktyka-Ekologia-Metrologia. -Vol. 23., iss. 1-2 (2018), s.113-126
DOI:
Digital Object Identifier (open in new tab) 10.1515/cdem-2018-0007
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Sources of funding:
  • IP2011 028071
Verified by:
Gdańsk University of Technology

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