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Injectable poloxamer/graphene oxide hydrogels with well‐controlled mechanical and rheological properties
Abstract
Although significant progress has been made in the design and application of injectable hydrogels for biomedical applications, concurrent control of rheological and mechanical properties of injectable hydrogels has remained as an open challenge to the researchers. In this work, we introduce and put into practice a photo‐curable poloxamer (also known as Pluronic)/graphene oxide (Plu/GO) injectable hydrogel with well‐controlled rheological and mechanical properties. Acrylate group was anchored to hydrogel structure to endow photo‐crosslinking ability through decelerating degradation rate of poloxamer hydrogels after injection. It was found that the modified Plu remains stable in biological media for a long‐term period without significant weight loss. Rheological properties of hydrogels were also carried out as essential prerequisite for an ideal injectability via frequency sweep, flow curve, recovery, and yield stress before and after modification, signifying shear‐thinning behavior of Plu/GO hydrogels with high recoverability. The viscosity of shear‐thinning‐like hydrogels dropped at higher shear stress, which facilitated injection process. Moreover, mechanical behavior of Plu was optimized by manipulating the content of Plu, degree of modification with reactive precursor, curing, and particularly incorporation of GO without deteriorating effects on rheological behavior of Plu.
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Authors (5)
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Elaheh Rohani
- The University of Adelaide, Adelaide, South Australia, Australia Faculty of Health and Medical Sciences
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Henri Vahabi
- Université de Lorraine, Metz, France CentraleSupélec, LMOPS
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Mohammad Saeb
- Université de Lorraine, Metz, France CentraleSupélec, LMOPS
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Sabu Thomas
- MG University,Kottayam, Kerala, India School of Chemical Sciences
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Keywords
Details
- Category:
- Articles
- Type:
- artykuły w czasopismach
- Published in:
-
POLYMERS FOR ADVANCED TECHNOLOGIES
no. 30,
pages 2250 - 2260,
ISSN: 1042-7147 - Language:
- English
- Publication year:
- 2019
- Bibliographic description:
- Rohani E., Vahabi H., Formela K., Saeb M., Thomas S.: Injectable poloxamer/graphene oxide hydrogels with well‐controlled mechanical and rheological properties// POLYMERS FOR ADVANCED TECHNOLOGIES -Vol. 30,iss. 9 (2019), s.2250-2260
- DOI:
- Digital Object Identifier (open in new tab) 10.1002/pat.4654
- Verified by:
- Gdańsk University of Technology
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