Search
Abstract
PURPOSE OF REVIEW: Localization of focal epileptic brain is critical for successful epilepsy surgery and focal brain stimulation. Despite significant progress, roughly half of all patients undergoing focal surgical resection, and most patients receiving focal electrical stimulation, are not seizure free. There is intense interest in high-frequency oscillations (HFOs) recorded with intracranial electroencephalography as potential biomarkers to improve epileptogenic brain localization, resective surgery, and focal electrical stimulation. The present review examines the evidence that HFOs are clinically useful biomarkers. RECENT FINDINGS: Performing the PubMed search 'High-Frequency Oscillations and Epilepsy' for 2013-2015 identifies 308 articles exploring HFO characteristics, physiological significance, and potential clinical applications. SUMMARY: There is strong evidence that HFOs are spatially associated with epileptic brain. There remain, however, significant challenges for clinical translation of HFOs as epileptogenic brain biomarkers: Differentiating true HFO from the high-frequency power changes associated with increased neuronal firing and bandpass filtering sharp transients. Distinguishing pathological HFO from normal physiological HFO. Classifying tissue under individual electrodes as normal or pathological. Sharing data and algorithms so research results can be reproduced across laboratories. Multicenter prospective trials to provide definitive evidence of clinical utility.
Citations
-
5 3
CrossRef
-
0
Web of Science
-
4 8
Scopus
Authors (3)
-
Jan Cymbalnik
- Mayo Systems Electrophysiology Laboratory Department of Neurology
-
-
Gregory A. Worrell
- Mayo Systems Electrophysiology Laboratory Department of Neurology
Cite as
Full text
full text is not available in portal
Keywords
Details
- Category:
- Articles
- Type:
- artykuł w czasopiśmie wyróżnionym w JCR
- Published in:
-
CURRENT OPINION IN NEUROLOGY
no. 29,
edition 2,
pages 175 - 181,
ISSN: 1350-7540 - Language:
- English
- Publication year:
- 2016
- Bibliographic description:
- Cymbalnik J., Kucewicz M., Worrell G.: Interictal high-frequency oscillations in focal human epilepsy// CURRENT OPINION IN NEUROLOGY. -Vol. 29, iss. 2 (2016), s.175-181
- DOI:
- Digital Object Identifier (open in new tab) 10.1097/wco.0000000000000302
- Verified by:
- Gdańsk University of Technology
seen 113 times
Recommended for you
Pathological and physiological high-frequency oscillations in focal human epilepsy
- A. Matsumoto,
- B. Brinkmann,
- S. M. Stead
- + 5 authors
Dissecting gamma frequency activities during human memory processing
- M. T. Kucewicz,
- B. M. Berry,
- V. Kremen
- + 13 authors
Gamma oscillations precede interictal epileptiform spikes in the seizure onset zone
- L. Ren,
- M. T. Kucewicz,
- J. Cymbalnik
- + 7 authors
High frequency oscillations are associated with cognitive processing in human recognition memory
- M. T. Kucewicz,
- J. Cymbalnik,
- J. Matsumoto
- + 8 authors