Interictal high-frequency oscillations in focal human epilepsy - Publikacja - MOST Wiedzy

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Interictal high-frequency oscillations in focal human epilepsy

Abstrakt

PURPOSE OF REVIEW: Localization of focal epileptic brain is critical for successful epilepsy surgery and focal brain stimulation. Despite significant progress, roughly half of all patients undergoing focal surgical resection, and most patients receiving focal electrical stimulation, are not seizure free. There is intense interest in high-frequency oscillations (HFOs) recorded with intracranial electroencephalography as potential biomarkers to improve epileptogenic brain localization, resective surgery, and focal electrical stimulation. The present review examines the evidence that HFOs are clinically useful biomarkers. RECENT FINDINGS: Performing the PubMed search 'High-Frequency Oscillations and Epilepsy' for 2013-2015 identifies 308 articles exploring HFO characteristics, physiological significance, and potential clinical applications. SUMMARY: There is strong evidence that HFOs are spatially associated with epileptic brain. There remain, however, significant challenges for clinical translation of HFOs as epileptogenic brain biomarkers: Differentiating true HFO from the high-frequency power changes associated with increased neuronal firing and bandpass filtering sharp transients. Distinguishing pathological HFO from normal physiological HFO. Classifying tissue under individual electrodes as normal or pathological. Sharing data and algorithms so research results can be reproduced across laboratories. Multicenter prospective trials to provide definitive evidence of clinical utility.

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Autorzy (3)

  • Zdjęcie użytkownika  Jan Cymbalnik

    Jan Cymbalnik

    • Mayo Systems Electrophysiology Laboratory Department of Neurology
  • Zdjęcie użytkownika dr Michał Tomasz Kucewicz

    Michał Tomasz Kucewicz dr

    • Mayo Systems Electrophysiology Laboratory Department of Neurology
  • Zdjęcie użytkownika  Gregory A. Worrell

    Gregory A. Worrell

    • Mayo Systems Electrophysiology Laboratory Department of Neurology

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Informacje szczegółowe

Kategoria:
Publikacja w czasopiśmie
Typ:
artykuł w czasopiśmie wyróżnionym w JCR
Opublikowano w:
CURRENT OPINION IN NEUROLOGY nr 29, wydanie 2, strony 175 - 181,
ISSN: 1350-7540
Język:
angielski
Rok wydania:
2016
Opis bibliograficzny:
Cymbalnik J., Kucewicz M., Worrell G.: Interictal high-frequency oscillations in focal human epilepsy// CURRENT OPINION IN NEUROLOGY. -Vol. 29, iss. 2 (2016), s.175-181
DOI:
Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.1097/wco.0000000000000302
Weryfikacja:
Politechnika Gdańska

wyświetlono 24 razy

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