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Abstract
In this paper, a spectroscopic method for determination of cyclosporine concentrations in biological fluids is presented. Blood plasma and hemoglobin solutions are chosen for the experiment. For various cyclosporine concentrations in blood plasma and hemoglobin, absorbance measurements in spectra range from 600 to 1100 nm are performed. The measurement results are analyzed by the use of a dedicated algorithm. The obtained data are characterized by a high coefficient of correlation R2, which is equal to 0.9461 and 0.9808 for blood plasma and hemoglobin, respectively. The proposed method enables the selective detection of cyclosporine level and could be applied in medicine and laboratory diagnostics. The obtained result can be the base to build the point‐of‐care CsA level detection optical sensor.
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Authors (6)
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Barbara Bułło‐Piontecka
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Michał Wąsowicz dr.
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Details
- Category:
- Articles
- Type:
- artykuł w czasopiśmie wyróżnionym w JCR
- Published in:
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Journal of Biophotonics
no. 12,
pages 1 - 6,
ISSN: 1864-063X - Language:
- English
- Publication year:
- 2019
- Bibliographic description:
- Marzejon M., Kosowska M., Majchrowicz D., Bułło‐piontecka B., Wąsowicz M., Szczerska M.: Label‐free optical detection of cyclosporine in biological fluids// Journal of Biophotonics. -Vol. 12, iss. 4 (2019), s.1-6
- DOI:
- Digital Object Identifier (open in new tab) 10.1002/jbio.201800273
- Sources of funding:
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- Statutory activity/subsidy
- Leading National Research Centre Scientific Consortium; Healthy Animal‐Safe Food. Grant Number: 05‐1/KNOW2/2015
- Narodowe Centrum Badań i Rozwoju. Grant Number: Techmatstrateg Diamsec 347324
- Narodowym Centrum Nauki. Grant Number: 2017/25/N/ST7/01610
- Verified by:
- Gdańsk University of Technology
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