The synthesis and structure of a potential immunosuppressant: N-mycophenoyl malonic acid dimethyl ester
Abstract
The synthesis of a potential immunosuppressant, i.e. dimethyl ester of N-mycophenoyl malonic acid was optimized in the reaction of mycophenolic acid (MPA) with amino malonic dimethyl ester in the presence of propanephosphonic anhydride (T3P) as a coupling reagent. The structural properties of the obtained MPA derivative were investigated by NMR, MS and single crystal X-ray diffraction methods. Theoretical considerations of conformational flexibility based on DFT calculations are presented
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- Articles
- Type:
- artykuł w czasopiśmie wyróżnionym w JCR
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JOURNAL OF MOLECULAR STRUCTURE
no. 1151,
pages 218 - 222,
ISSN: 0022-2860 - Language:
- English
- Publication year:
- 2018
- Bibliographic description:
- Siebert A., Cholewiński G., Garwolińska D., Olejnik A., Rachoń J., Chojnacki J.: The synthesis and structure of a potential immunosuppressant: N-mycophenoyl malonic acid dimethyl ester// JOURNAL OF MOLECULAR STRUCTURE. -Vol. 1151, (2018), s.218-222
- DOI:
- Digital Object Identifier (open in new tab) 10.1016/j.molstruc.2017.09.041
- Bibliography: test
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- Gdańsk University of Technology
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