Search
The synthesis and structure of a potential immunosuppressant: N-mycophenoyl malonic acid dimethyl ester
Abstract
The synthesis of a potential immunosuppressant, i.e. dimethyl ester of N-mycophenoyl malonic acid was optimized in the reaction of mycophenolic acid (MPA) with amino malonic dimethyl ester in the presence of propanephosphonic anhydride (T3P) as a coupling reagent. The structural properties of the obtained MPA derivative were investigated by NMR, MS and single crystal X-ray diffraction methods. Theoretical considerations of conformational flexibility based on DFT calculations are presented
Citations
-
4
CrossRef
-
0
Web of Science
-
4
Scopus
Authors (6)
Cite as
Full text
download paper
downloaded 52 times
- Publication version
- Accepted or Published Version
- License
-
open in new tab
Keywords
Details
- Category:
- Articles
- Type:
- artykuł w czasopiśmie wyróżnionym w JCR
- Published in:
-
JOURNAL OF MOLECULAR STRUCTURE
no. 1151,
pages 218 - 222,
ISSN: 0022-2860 - Language:
- English
- Publication year:
- 2018
- Bibliographic description:
- Siebert A., Cholewiński G., Garwolińska D., Olejnik A., Rachoń J., Chojnacki J.: The synthesis and structure of a potential immunosuppressant: N-mycophenoyl malonic acid dimethyl ester// JOURNAL OF MOLECULAR STRUCTURE. -Vol. 1151, (2018), s.218-222
- DOI:
- Digital Object Identifier (open in new tab) 10.1016/j.molstruc.2017.09.041
- Verified by:
- Gdańsk University of Technology
seen 200 times