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White light thermoplasmonic activated gold nanorod arrays enable the photo-thermal disinfection of medical tools from bacterial contamination
Abstract
The outspread of bacterial pathogens causing severe infections and spreading rapidly, especially among hospitalized patients, is worrying and represents a global public health issue. Current disinfection techniques are becoming insufficient to counteract the spread of these pathogens because they carry multiple antibiotic-resistance genes. For this reason, a constant need exists for new technological solutions that rely on physical methods rather than chemicals. Nanotechnology support provides novel and unexplored opportunities to boost groundbreaking, next-gen solutions. With the help of plasmonicassisted nanomaterials, we present and discuss our findings in innovative bacterial disinfection techniques. Gold nanorods (AuNRs) immobilized on rigid substrates are utilized as efficient white lightto-heat transducers (thermoplasmonic effect) for photo-thermal (PT) disinfection. The resulting AuNRs array shows a high sensitivity change in refractive index and an extraordinary capability in converting white light to heat, producing a temperature change greater than 50 1C in a few minute interval illumination time. Results were validated using a theoretical approach based on a diffusive heat transfer model. Experiments performed with a strain of Escherichia coli as a model microorganism confirm the excellent capability of the AuNRs array to reduce the bacteria viability upon white light illumination. Conversely, the E. coli cells remain viable without white light illumination, which also confirms the lack of intrinsic toxicity of the AuNRs array. The PT transduction capability of the AuNRs array is utilized to produce white light heating of medical tools used during surgical treatments, generating a temperature increase that can be controlled and is suitable for disinfection. Our findings are pioneering a new opportunity for healthcare facilities since the reported methodology allows non-hazardous disinfection of medical devices by simply employing a conventional white light lamp.
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Authors (14)
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Federica Zaccagnini
- Department of Medico-Surgical Sciences and Biotechnologies Sapienza University of Rome, Latina, Italy
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Maria Laura Sforza
- Department of Medico-Surgical Sciences and Biotechnologies Sapienza University of Rome, Latina, Italy
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Seok-In Lim
- Department of Polymer-Nano Science and Technology, Department of Nano Convergence Engineering, Jeonbuk National University, Jeonju, Republic of Korea
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Kwang-un Jeong
- Department of Polymer-Nano Science and Technology, Department of Nano Convergence Engineering, Jeonbuk National University, Jeonju, Republic of Korea
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Nicholas P. Godman
- Air Force Research Laboratory, Materials and Manufacturing Directorate, Wright-Patterson Air Force Base, Ohio, USA
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Dean R. Evans
- Air Force Research Laboratory, Materials and Manufacturing Directorate, Wright-Patterson Air Force Base, Ohio, USA
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Jonathan E. Slagle
- Air Force Research Laboratory, Materials and Manufacturing Directorate, Wright-Patterson Air Force Base, Ohio, USA
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Michael E. Mcconney
- Air Force Research Laboratory, Materials and Manufacturing Directorate, Wright-Patterson Air Force Base, Ohio, USA
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Daniela De Biase
- Department of Medico-Surgical Sciences and Biotechnologies Sapienza University of Rome, Latina, Italy
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Francesca Petronella
- Department of Medico-Surgical Sciences and Biotechnologies Sapienza University of Rome, Latina, Italy
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Luciano de Sio profesor
- Department of Medico-Surgical Sciences and Biotechnologies Sapienza University of Rome, Latina, Italy
Cite as
Full text
- Publication version
- Accepted or Published Version
- DOI:
- Digital Object Identifier (open in new tab) 10.1039/d3tb00865g
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Details
- Category:
- Articles
- Type:
- artykuły w czasopismach
- Published in:
-
Journal of Materials Chemistry B
no. 11,
pages 6823 - 6836,
ISSN: 2050-750X - Language:
- English
- Publication year:
- 2023
- Bibliographic description:
- Zaccagnini F., Radomski P., Sforza M. L., Ziółkowski P., Lim S., Jeong K., Mikielewicz D., Godman N. P., Evans D. R., Slagle J. E., Mcconney M. E., De Biase D., Petronella F., de Sio L.: White light thermoplasmonic activated gold nanorod arrays enable the photo-thermal disinfection of medical tools from bacterial contamination// Journal of Materials Chemistry B -,iss. 29 (2023), s.6823-6836
- DOI:
- Digital Object Identifier (open in new tab) 10.1039/d3tb00865g
- Sources of funding:
- Verified by:
- Gdańsk University of Technology
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