Filters
total: 2780
filtered: 1394
displaying 1000 best results Help
Search results for: ANTI-CANCER AGENTS
-
The metabolic profiles of pterin compounds as potential biomarkers of bladder cancer—Integration of analytical-based approach with biostatistical methodology
Publication -
S-seco-porphyrazine as a new member of the seco-porphyrazine family – Synthesis, characterization and photocytotoxicity against cancer cells
Publication -
Fluorescence resonance energy transfer usage to track the sequence promoter changes in CGB5 gene in ovarian cancer patients
Publication -
Ultrasensitive electrochemical determination of the cancer biomarker protein sPD-L1 based on a BMS-8-modified gold electrode
PublicationThis work describes the modification of a gold electrode with the BMS-8 compound that interacts with the Programmed Death-Ligand 1 (PD-L1), an immune checkpoint protein. The results show that we can confirm the presence of the sPD-L1 in the concentration range of 10−18 to 10−8 M using electrochemical impedance spectroscopy (EIS) with a limit of detection (LOD) of 1.87 × 10−14 M for PD-L1 (S/N = 3.3) and at a concentration of 10−14...
-
Pregnane X receptor dependent up-regulation of CYP2C9 and CYP3A4 in tumor cells by antitumor acridine agents, C-1748 and C-1305, selectively diminished under hypoxia
PublicationInduction of proteins involved in drug metabolism and in drug delivery has a significant impact on drug-drug interactions and on the final therapeutic effects. Two antitumor acridine derivatives selected for present studies, C-1748 (9-(2’-hydroxyethylamino)-4-methyl-1-nitroacridine) and C-1305 (5-dimethylaminopropylamino-8-hydroxy-triazoloacridinone), expressed high and low susceptibility to metabolic transformations with liver...
-
Identification of X-DING-CD4, a new member of human DING protein family that is secreted by HIV-1 resistant CD4+ T cells and has anti-viral activity
Publication -
Radiation damage of biomolecular systems: Nano-scale insights into Ion-beam cancer therapy. 2nd Nano-IBCT conference
Publication -
Application of Bayesian networks for inferring cause–effect relations from gene expression profiles of cancer versus normal cells
Publication -
Mass spectrometry-based analysis of therapy-related changes in serum proteome patterns of patients with early-stage breast cancer
Publication -
OC-0265: Whole body response to radiation in head and neck and prostate cancer patient; the serum proteome comparative analysis
Publication -
Genotoxicity of selected pharmaceuticals, their binary mixtures, and varying environmental conditions – study with human adenocarcinoma cancer HT29 cell line
PublicationPharmaceutical residues are present in the environment in mixtures and their adverse effects may also result from interactions that occur between compounds. Studies presented in this work focus on genotoxicity of pharmaceuticals from different therapeutic groups in mixtures and in individual solutions impacted with different environmental conditions assessed using comet assay (alkaline approach). Binary mixtures of pharmaceuticals...
-
LC-PDA-MS and GC-MS Analysis of Scorzonera hispanica Seeds and Their Effects on Human Breast Cancer Cell Lines
Publication -
P3.13-032 The Impact of Tobacco Exposure on Lung Nodules and Emphysema in a Pilot Silesian Study of Early Lung Cancer with LDCT
Publication -
The effect of cabbage juice and it's active components on the protein level and expression of CYP19 in MCF-7 breast cancer cells
PublicationWiadomo, że bioaktywne skladniki kapusty mają chemoprewencyjne działanie w przypadku nowotworów piersi, między innymi ze względu na hamowanie aktywności enzymu aromatazy uczestniczącego w biosyntezie estrogenów. Badania prowadzono przy użyciu komórek raka piersi i stwierdzono, że soki z kapusty, zarówno pochodzącej z uprawy ekologicznej jak i przemysłowej, znacząco hamowały ekspresję genu CYP19 kodującego wspomniany enzym. Sugeruje...
-
Self-organizing maps classification of epidemiological data and toenail selenium content monitored on cancer and healthy patients from Poland
PublicationW pracy przedstawiono wyniki wielowymiarowej analizy danych pomiarowych (przy wykorzystaniu techniki samoorganizującej sie mapy (SOM))nad oszacowaniem zawartości selenu w próbkach paznokci pobranych od mieszkańców Województwa Pomorskiego ((w tym od grupy osób zdrowych i ze zdiagnozowaną chorobą nowotworową) i Lubuskiego. W wyniku przeprowadzonej analizy uzyskano podział uczestników ze zdiagnozowanym nowotworem na trzy różne grupy:1...
-
Nanosecond pulsed electric fields (nsPEFs) impact and enhanced Photofrin II® delivery in photodynamic reaction in cancer and normal cells
Publication -
Characteristic profiles of DNA epigenetic modifications in colon cancer and its predisposing conditions—benign adenomas and inflammatory bowel disease
Publication -
Expression of stem cell and mesenchymal markers in circulating tumor cells is associated with poor prognosis of early breast cancer patients
Publication -
Biofilm Growth Causes Damage to Silicone Voice Prostheses in Patients after Surgical Treatment of Locally Advanced Laryngeal Cancer
Publication -
Expression of Osteoblast-Specific Factor 2 (OSF-2, Periostin) Is Associated with Drug Resistance in Ovarian Cancer Cell Lines
Publication -
PTPRK Expression Is Downregulated in Drug Resistant Ovarian Cancer Cell Lines, and Especially in ALDH1A1 Positive CSCs-Like Populations
Publication -
Deep Learning-based Recalibration of the CUETO and EORTC Prediction Tools for Recurrence and Progression of Non–muscle-invasive Bladder Cancer
Publication -
Validation of the Polish version of the EORTC QLQ-OV28 module for the assessment of health-related quality of life in women with ovarian cancer
Publication -
Discussion on 3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibitors reduce human pancreatic cancer cell invasion and metastasis
Publication -
Urine metabolic fingerprinting using LC–MS and GC–MS reveals metabolite changes in prostate cancer: A pilot study
Publication -
Metabolic Evaluation of Urine from Patients Diagnosed with High Grade (HG) Bladder Cancer by SPME-LC-MS Method
Publication -
Diazepinoporphyrazines Containing Peripheral Styryl Substituents and Their Promising Nanomolar Photodynamic Activity against Oral Cancer Cells in Liposomal Formulations
Publication -
2,7-Dihydro-3H-pyridazino[5,4,3-kl]acridin-3-one derivatives, novel type of cytotoxic agents active on multidrug-resistant cell lines. Synthesis and biological evaluation.
PublicationOtrzymano serię pirydazyno akrydyn-3-onów w reakcji 9-okso-9,10-dihydroakrydyno-1-karboksylanu etylu z POCl3, następnie dodanie odpowiedniej alkiloaminoalkilohydrazyny. Badane związki wykazują w porównaniu z referencyjnymi cytostatykami DX, MIT niższe wartości indeksu RI, a także niższe aktywności cytotoksyczne.
-
Human CYP2 family of cytochrome P-450 takes part in metabolism of two acridine antitumor agents, C-1311 and C-1748, selected for I phase of clinical trials
PublicationPraca zawiera wyniki badań metabolicznej transformacji przeciwnowotworowych pochodnych akrydyny wobec zestawu 16 prób enzymów mikrosomalnych, pochodzących z wątroby 16 różnych pacjentów. Wykazano, że za metabolizm tych związków u człowieka odpowiedzialne są głównie izoenzymy z rodziny CYP2.
-
Simultaneous analysis of non-steroidal anti-inflammatory drugs and estrogenic hormones in water and wastewater samples using gas chromatography–mass spectrometry and gas chromatography with electron capture detection
Publication -
Synthesis and biological evaluation of 2,7-Dihydro-3H-dibenzo[de,h]cinnoli- ne-3,7-done derivatives a novel group of anticancer agents active on a multidrug resistance cell line.
PublicationZsyntezowano serię pochodnych pirydazonu z jednym lub dwoma łańcuchami bocznymi w różnych pozycjach chromoforu tetracyklicznego. Związki wykazały aktywność cytoksyczną na mysią białaczkę L1210 i ludzką k562 oraz na linii komórkowej oporności krzyżowej MDR (k562/DX). Dwa najbardziej aktywne związki przetestowano in vivo na mysiej białaczce P388. Wykazały one aktywność przeciwnowotworową porównywalną z aktywnością Mitoxantronu.
-
Signatures of post-zygotic structural genetic aberrations in the cells of histologically normal breast tissue that can predispose to sporadic breast cancer
Publication -
Expression of epithelial to mesenchymal transition-related markers in lymph node metastases as a surrogate for primary tumor metastatic potential in breast cancer
Publication -
Increased plasma concentration of 4-pyridone-3-carboxamide-1-ß-D-ribonucleoside (4PYR) in lung cancer. Preliminary studies
Publication -
Complementary and alternative medicine (CAM) use among patients with cancer undergoing palliative care: A pilot study of a single institution in Poland.
Publication -
Molecular Heterogeneity of Papillary Thyroid Cancer: Comparison of Primary Tumors and Synchronous Metastases in Regional Lymph Nodes by Mass Spectrometry Imaging
Publication -
Relationships between acute reactions to radiotherapy in head and neck cancer patients and parameters of radiation-induced DNA damage and repair in their lymphocytes
Publication -
Radiation-related Changes in Serum Proteome Profiles Detected by Mass Spectrometry in Blood of Patients Treated with Radiotherapy Due to Larynx Cancer
Publication -
Radiation-related Changes in Serum Proteome Profiles Detected by Mass Spectrometry in Blood of Patients Treated with Radiotherapy Due to Larynx Cancer
Publication -
(1→3)-α-d-Glucooligosaccharides Increase the Killing Capacity of NK Cells against Selected Human Colon Cancer Cells
Publication -
A Pilot Study Indicates an Essential Link between a Mild Deterioration in Excretory Kidney Function and the Risk of Neutropenia during Cancer Chemotherapy
Publication -
Detection of MGMT, RASSF1A, p15INK4B, and p14ARF promoter methylation in circulating tumor-derived DNA of central nervous system cancer patients
Publication -
Proteomic Profiling of Ectosomes Derived from Paired Urothelial Bladder Cancer and Normal Cells Reveals the Presence of Biologically-Relevant Molecules
Publication -
The influence of 4-substituted and unsubstituted derivatives of 1-nitroacridine on the cell cycle and induction of apoptosis in human cancer HT29 and HeLa S3.
PublicationZbadano wpływ pochodnych 1-nitroakrydyny C-1748 i C-857, w stężeniach biologicznie istotnych, na cykl życiowy oraz indukcję apoptozy komórek raka jelita grubego HT29 oraz raka szyjki macicy HeLa S3. Metodą cytometrii przepływowej wykazano, że 4-metylo-1-nitroakrydyna C-1748 powoduje akumulację komórek HT29 w fazie S i komórek HeLa S3 w fazie G2 cyklu komórkowego zaś związek C-857 indukuje akumulację komórek HT29 i HeLa S3 w fazie...
-
Correction to: Plasma free amino acid profiling as metabolomic diagnostic and prognostic biomarker in paediatric cancer patients: a follow-up study
Publication -
Piperine Targets Different Drug Resistance Mechanisms in Human Ovarian Cancer Cell Lines Leading to Increased Sensitivity to Cytotoxic Drugs
Publication -
The Significance of MicroRNAs Expression in Regulation of Extracellular Matrix and Other Drug Resistant Genes in Drug Resistant Ovarian Cancer Cell Lines
Publication -
Triple Combination of Ascorbate, Menadione and the Inhibition of Peroxiredoxin-1 Produces Synergistic Cytotoxic Effects in Triple-Negative Breast Cancer Cells
Publication -
Cyclic voltammetric biosensing of cellular ionic secretion based on silicon nanowires to detect the effect of paclitaxel on breast normal and cancer cells
Publication -
C421 allele-specific ABCG2 gene amplification confers resistance to the antitumor triazoloacridone C-1305 in human lung cancer cells
PublicationGen ABCG2 charakteryzuje polimorficzność pozycji C341, która jest związana ze znacznym obniżeniem ekspresji tego genu i zdolności do transportu przez błonę komórkową. W pracy wykazaliśmy, że komórki raka płuc, które nabyły oporności na związek C-1305, zmieniły fenotyp z heterozygotycznego w odniesieniu do genu ABCG2 i wykazują amplifikację jedynie allelu C341 genu oraz zwiększoną zawartość mRNA i zmutowanego białka pompy ABCG2...