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Search results for: DAP
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Synthesis of 2,6-diaminopimelic acid (DAP) and its analogues
PublicationKwas 2,6-diaminopimelinowy jest ważnym aminokwasem biosyntetyzowanym przez bakterie i wyższe rośliny. Liczne fragmenty peptydoglikanu zawierające reszty kwasu diaminopimelinowego wykazują aktywność przeciwnowotworową i/lub immunostymulacyjną. W artykule opisano sposoby syntezy kwasu 2,6-diaminopimelinowego i jego analogi.
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Daphnia magna model in the toxicity assessment of pharmaceuticals: A review
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Experimental Study of Dapped-End Beams Subjected to Inclined Load
PublicationThis paper presents the results of an experimental investigation of the reinforced concrete (RC) dapped-end beams loaded with inclined forces, compared to identical ones loaded with vertical forces only. Such a load may occur in, for example, Gerber's joints or in dapped-end beams supported on corbels, where the vertical gravitation force is additionally completed with horizontal forces caused by temperature differences, shrinking,...
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Identification of Mitochondrial DNA (NUMTs) in the Nuclear Genome of Daphnia magna
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Discussion - Experimental study of dapped–end beams subjected to inclined load
PublicationDiscussion - Experimental study of dapped–end beams subjected to inclined load
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Increasing rate of daptomycin non-susceptible strains of Staphylococcus aureus in patients with atopic dermatitis
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Intermolecular Interactions as a Measure of Dapsone Solubility in Neat Solvents and Binary Solvent Mixtures
PublicationDapsone is an effective antibacterial drug used to treat a variety of conditions. However, the aqueous solubility of this drug is limited, as is its permeability. This study expands the available solubility data pool for dapsone by measuring its solubility in several pure organic solvents: N-methyl-2-pyrrolidone (CAS: 872-50-4), dimethyl sulfoxide (CAS: 67-68-5), 4-formylmorpholine (CAS: 4394-85-8), tetraethylene pentamine (CAS:...
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Solubility of dapsone in deep eutectic solvents: Experimental analysis, molecular insights and machine learning predictions
PublicationBackground. Dapsone (DAP) is an anti-inflammatory and antimicrobial active pharmaceutical ingredient used to treat, e.g., AIDS-related diseases. However, low solubility is a feature hampering its efficient use. Objectives. First, deep eutectic solvents...
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Experimental and Theoretical Insights into the Intermolecular Interactions in Saturated Systems of Dapsone in Conventional and Deep Eutectic Solvents
PublicationSolubility is not only a crucial physicochemical property for laboratory practice but also provides valuable insight into the mechanism of saturated system organization, as a measure of the interplay between various intermolecular interactions. The importance of these data cannot be overstated, particularly when dealing with active pharmaceutical ingredients (APIs), such as dapsone. It is a commonly used anti-inflammatory and...
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Novel Cell Permeable Polymers of N-Substituted L-2,3-Diaminopropionic Acid (DAPEGs) and Cellular Consequences of Their Interactions with Nucleic Acids
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Chemometric modeling of aquatic toxicity of contaminants of emerging concern (CECs) in Dugesia japonica and its interspecies correlation with daphnia and fish: QSTR and QSTTR approaches
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INFLUENCE OF A VERTEX REMOVING ON THE CONNECTED DOMINATION NUMBER – APPLICATION TO AD-HOC WIRELESS NETWORKS
PublicationA minimum connected dominating set (MCDS) can be used as virtual backbone in ad-hoc wireless networks for efficient routing and broadcasting tasks. To find the MCDS is an NP- complete problem even in unit disk graphs. Many suboptimal algorithms are reported in the literature to find the MCDS using local information instead to use global network knowledge, achieving an important reduction in complexity. Since a wireless network...
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Isolation Number versus Domination Number of Trees
PublicationIf G=(VG,EG) is a graph of order n, we call S⊆VG an isolating set if the graph induced by VG−NG[S] contains no edges. The minimum cardinality of an isolating set of G is called the isolation number of G, and it is denoted by ι(G). It is known that ι(G)≤n3 and the bound is sharp. A subset S⊆VG is called dominating in G if NG[S]=VG. The minimum cardinality of a dominating set of G is the domination number, and it is denoted by γ(G)....
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Mechanical Properties of Twisted Carbon Nanotube Bundles with Carbon Linkers from Molecular Dynamics Simulations
PublicationThe manufacturing of high-modulus, high-strength fibers is of paramount importance for real-world, high-end applications. In this respect, carbon nanotubes represent the ideal candidates for realizing such fibers. However, their remarkable mechanical performance is difficult to bring up to the macroscale, due to the low load transfer within the fiber. A strategy to increase such load transfer is the introduction of chemical linkers...
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The Role of Molecular Structure in Monte Carlo Simulations of the Secondary Electron Yield and Backscattering Coefficient from Methacrylic Acid
PublicationIn this paper, we show the influence of the chemical structure of four different conformers on the secondary electron emission and backscattering of an electron beam from a gel of methacrylic acid. The conformers have different permanent dipole moments, which determines the cross sections for elastic collisions with electrons. The cross sections are used in Monte Carlo simulations of an electron beam, which enters the gel of methacrylic...
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The role of low-energy electrons in the charging process of LISA test masses
PublicationThe estimate of the total electron yield is fundamental for our understanding of the test-mass charging associated with cosmic rays in the Laser Interferometer Space Antenna (LISA) Pathfinder mission and in the forthcoming gravitational wave observatory LISA. To unveil the role of low energy electrons in this process owing to galactic and solar energetic particle events, in this work we study the interaction of keV and sub-keV...
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Serum miRNA-based signature indicates radiation exposure and dose in humans: a multicenter diagnostic biomarker study
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Serum miRNA-based signature indicates radiation exposure and dose in humans: A multicenter diagnostic biomarker study
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Tailoring Graphene to Achieve Negative Poisson's Ratio Properties
PublicationGraphene can be made auxetic through the introduction of vacancy defects. This results in the thinnest negative Poisson's ratio material at ambient conditions known so far, an effect achieved via a nanoscale de-wrinkling mechanism that mimics the behavior at the macroscale exhibited by a crumpled sheet of paper when stretched.
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O07 Filaggrin insufficiency renders keratinocyte-derived small extracellular vesicles capable of affecting CD1a-mediated T-cell responses and promoting allergic inflammation
PublicationThe association between FLG loss-of-function mutations and the development of atopic dermatitis (AD) indicates that filaggrin is critical to skin barrier function; the mutations are also linked to additional allergic manifestations, but it is unknown how the skin may influence inflammation in distant tissues. Here we investigated the impact of filaggrin insufficiency on keratinocyte-derived exosome-enriched small extracellular...
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Keratinocyte-derived small extracellular vesicles supply antigens for CD1a-resticted T cells and promote their type 2 bias in the context of filaggrin insufficiency
PublicationIntroduction: Exosome-enriched small extracellular vesicles (sEVs) are nanosized organelles known to participate in long distance communication between cells, including in the skin. Atopic dermatitis (AD) is a chronic inflammatory skin disease for which filaggrin (FLG) gene mutations are the strongest genetic risk factor. Filaggrin insufficiency affects multiple cellular function, but it is unclear if sEV-mediated cellular communication...
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Comparison of different digestion methods for proteomic analysis of isolated cells and FFPE tissue samples
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Blind prediction of homo‐ and hetero‐protein complexes: The CASP13‐CAPRI experiment
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Prediction of protein assemblies, the next frontier: The CASP14‐CAPRI experiment
PublicationWe present the results for CAPRI Round 50, the 4th joint CASP-CAPRI protein assembly prediction challenge. The Round comprised a total of 12 targets, including 6 dimers, 3 trimers, and 3 higher-order oligomers. Four of these were easy targets, for which good structural templates were available either for the full assembly, or for the main interfaces (of the higher-order oligomers). Eight were difficult targets for which only distantly...
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Impact of AlphaFold on structure prediction of protein complexes: The CASP15‐CAPRI experiment
PublicationWe present the results for CAPRI Round 54, the 5th joint CASP-CAPRI protein assembly prediction challenge. The Round offered 37 targets, including 14 homodimers, 3 homo-trimers, 13 heterodimers including 3 antibody–antigen complexes, and 7 large assemblies. On average 70 CASP and CAPRI predictor groups, including more than 20 automatics servers, submitted models for each target. A total of 21 941 models submitted by these groups...
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Global 30-day outcomes after bariatric surgery during the COVID-19 pandemic (GENEVA): an international cohort study
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Safety of Bariatric Surgery in ≥ 65-Year-Old Patients During the COVID-19 Pandemic
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30-Day Morbidity and Mortality of Bariatric Surgery During the COVID-19 Pandemic: a Multinational Cohort Study of 7704 Patients from 42 Countries
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Effect of BMI on safety of bariatric surgery during the COVID-19 pandemic, procedure choice, and safety protocols – An analysis from the GENEVA Study
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30-day morbidity and mortality of sleeve gastrectomy, Roux-en-Y gastric bypass and one anastomosis gastric bypass: a propensity score-matched analysis of the GENEVA data
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Desmuramylopeptydy - struktura i aktywność biologiczna = Desmuramylpeptide - structure and biological activity
PublicationWśród fragmentów bakteryjnych ścian komórkowych, ktore wzbudzają duże zainteresowanie, są tak zwane desmuramylopeptydy. Są to cząsteczki nie zawierające reszty kwasu muraminowego. W niniejszym artykule opisano desmuramylopeptydy, które z uwagi na swoje właściwości farmakologiczne, takie jak stymulowanie niespecyficznej odporności przeciwbakteryjnej, aktywność przeciwwirusową i przeciwnowotworową oraz synergistyczne oddziaływanie...
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Handling of the Covid-19 Pandemic and Its Effects on Bariatric Surgical Practice: Analysis of GENEVA Study Database
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The CMS experiment at the CERN LHC
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