Search results for: TACRINE

• Therapeutic Potential of Multifunctional Tacrine Analogues

  Publication

  • M. Przybyłowska
  • K. Szymon
  • K. Dzierzbicka
  • I. Inkielewicz-Stępniak

  - Current Neuropharmacology - Year 2019

  Tacrine is a potent inhibitor of cholinesterases (acetylcholinesterase and butyrylcholinesterase) that shows limiting clinical application by liver toxicity. In spite of this, analogues of tacrine are considered as a model inhibitor of cholinesterases in the therapy of Alzheimer’s disease. The interest in these compounds is mainly related to a high variety of their structure and biological properties. In the present review, we...

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• MARINE POLLUTION BULLETIN

  Journals

  ISSN: 0025-326X , eISSN: 1879-3363

• Journal of Machine Construction and Maintenance

  Journals

  ISSN: 1232-9312 , eISSN: 2300-1186

• Comparing combined gas tubrine/steam turbine and marine low speed piston engine/steam turbine systems in naval applications

  Publication

  • M. Dzida
  • W. Olszewski

  - Polish Maritime Research - Year 2011

  Porównano układy napędowe okrętowe kombinowane turbina gazowa- turbina parowa oraz spalinowy okrętowy silnik tłokowy wolnoobrotowy - turbina parowa. Porównywano moce oraz zużycie paliwa oraz parametry pary świeżej układu turbiny parowej.

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• Energy Versus Throughput Optimisation for Machine-to-Machine Communication

  Publication

  • E. Fitzgerald
  • M. Pióro
  • A. Tomaszewski

  - SENSORS - Year 2020

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• Journal of Marine Science and Engineering

  Journals

  ISSN: 2077-1312

• Synthesis and Cholinesterase Inhibitory Activity of N-Phosphorylated /N-Tiophosphorylated Tacrine

  Publication

  • M. Przybyłowska
  • I. Inkielewicz-Stępniak
  • S. Kowalski
  • K. Dzierzbicka
  • S. Demkowicz
  • M. Daśko

  - Medicinal Chemistry - Year 2020

  Novel phosphorus and thiophosphorus tacrine derivatives were designed, synthesized and their biological activity and molecular modeling was investigated as a new potential anti-Alzheimer's disease (AD) agents. All new synthesized compound exhibited lower toxicity against neuroblastoma cell line (SH-SY5Y) in comparison with tacrine. Two analogues in the series, 7 and 9, demonstrated lack of cytotoxicity against hepatocellular cells...

• MARINE STRUCTURES

  Journals

  ISSN: 0951-8339 , eISSN: 1873-4170

• Marine Technology Transactions. Technika Morska

  Journals

  ISSN: 1230-2341

• Taurine as a water structure breaker and protein stabilizer

  Publication

  • P. Bruździak
  • A. Panuszko
  • E. Kaczkowska
  • B. Piotrowski
  • A. Daghir
  • S. Demkowicz
  • J. Stangret

  - AMINO ACIDS - Year 2018

  The enhancing effect on the water structure has been confirmed for most of the osmolytes exhibiting both stabilizing and destabilizing properties in regard to proteins. The presented work concerns osmolytes, which should be classified as “structure breaking” solutes: taurine and N,N,N-trimethyltaurine (TMT). Here, we combine FTIR spectroscopy, DSC calorimetry and DFT calculations to gain an insight into the interactions between...

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