Search results for: tacrine

• MARINE POLLUTION BULLETIN

  Journals

  ISSN: 0025-326X , eISSN: 1879-3363

• Therapeutic Potential of Multifunctional Tacrine Analogues

  Publication

  • M. Przybyłowska
  • K. Szymon
  • K. Dzierzbicka
  • I. Inkielewicz-Stępniak

  - Current Neuropharmacology - Year 2019

  Tacrine is a potent inhibitor of cholinesterases (acetylcholinesterase and butyrylcholinesterase) that shows limiting clinical application by liver toxicity. In spite of this, analogues of tacrine are considered as a model inhibitor of cholinesterases in the therapy of Alzheimer’s disease. The interest in these compounds is mainly related to a high variety of their structure and biological properties. In the present review, we...

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• Journal of Machine Construction and Maintenance

  Journals

  ISSN: 1232-9312 , eISSN: 2300-1186

• VACCINE

  Journals

  ISSN: 0264-410X , eISSN: 1873-2518

• MARINE STRUCTURES

  Journals

  ISSN: 0951-8339 , eISSN: 1873-4170

• Journal of Marine Science and Engineering

  Journals

  ISSN: 2077-1312

• Comparing combined gas tubrine/steam turbine and marine low speed piston engine/steam turbine systems in naval applications

  Publication

  • M. Dzida
  • W. Olszewski

  - Polish Maritime Research - Year 2011

  Porównano układy napędowe okrętowe kombinowane turbina gazowa- turbina parowa oraz spalinowy okrętowy silnik tłokowy wolnoobrotowy - turbina parowa. Porównywano moce oraz zużycie paliwa oraz parametry pary świeżej układu turbiny parowej.

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• Energy Versus Throughput Optimisation for Machine-to-Machine Communication

  Publication

  • E. Fitzgerald
  • M. Pióro
  • A. Tomaszewski

  - SENSORS - Year 2020

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• Marine Technology Transactions. Technika Morska

  Journals

  ISSN: 1230-2341

• Synthesis and Cholinesterase Inhibitory Activity of N-Phosphorylated /N-Tiophosphorylated Tacrine

  Publication

  • M. Przybyłowska
  • I. Inkielewicz-Stępniak
  • S. Kowalski
  • K. Dzierzbicka
  • S. Demkowicz
  • M. Daśko

  - Medicinal Chemistry - Year 2020

  Novel phosphorus and thiophosphorus tacrine derivatives were designed, synthesized and their biological activity and molecular modeling was investigated as a new potential anti-Alzheimer's disease (AD) agents. All new synthesized compound exhibited lower toxicity against neuroblastoma cell line (SH-SY5Y) in comparison with tacrine. Two analogues in the series, 7 and 9, demonstrated lack of cytotoxicity against hepatocellular cells...