Search results for: Bernard Tschumi
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Human Gb3/CD77 synthase produces P1 glycotope-capped N-glycans, which mediate Shiga toxin 1 but not Shiga toxin 2 cell entry
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CAVER Analyst 1.0: graphic tool for interactive visualization and analysis of tunnels and channels in protein structures
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Boron doped carbon nanotubes via ceramic catalysts
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A general approach to study molecular fragmentation and energy redistribution after an ionizing event
PublicationWe propose to combine quantum chemical calculations, statistical mechanical methods, and photoionization and particle collision experiments to unravel the redistribution of internal energy of the furan cation and its dissociation pathways. This approach successfully reproduces the relative intensity of the different fragments as a function of the internal energy of the system in photoelectron–photoion coincidence experiments and...
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The modelling and enhancement of water hydrodynamics: general discussion
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InfraNoise A system for precise monitoring of the impact of railway traffic on the environment, taking into account information on operational, technical and environmental data
ProjectsProject realized in Department of Transportation Engineering according to BRIK2/0020/2022-00 agreement from 2022-10-27
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In situ observations of fullerene fusion and ejection in carbon nanotubes
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Correlation between in vitro and in vivo data on food digestion. What can we predict with static in vitro digestion models?
PublicationDuring the last decade, there has been a growing interest in understanding food's digestive fate in order to strengthen the possible effects of food on human health. Ideally, food digestion should be studied in vivo on humans but this is not always ethically and financially possible. Therefore, simple in vitro digestion models mimicking the gastrointestinal tract have been proposed as alternatives to in vivo experiments. Thus,...
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Structure and function of natural proteins for water transport: general discussion
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The fast beam condition monitor BCM1F backend electronics upgraded MicroTCA-based architecture
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Carbon nanotube synthesis via ceramic catalysts
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The Global Boundary Stratotype Section and Point (GSSP) for the base of the Coniacian Stage (Salzgitter-Salder, Germany) and its auxiliary sections (Słupia Nadbrzeżna, central Poland; Střeleč, Czech Republic; and El Rosario, NE Mexico)
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Advancing electrochemical impedance analysis through innovations in the distribution of relaxation times method
PublicationElectrochemical impedance spectroscopy (EIS) is widely used in electrochemistry, energy sciences, biology, and beyond. Analyzing EIS data is crucial, but it often poses challenges because of the numerous possible equivalent circuit models, the need for accurate analytical models, the difficulties of nonlinear regression, and the necessity of managing large datasets within a unified framework. To overcome these challenges, non-parametric...
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Postibrutinib outcomes in patients with mantle cell lymphoma
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2018 ESC/ESH Guidelines for the management of arterial hypertension
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Caspase-11 promotes allergic airway inflammation
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A standardised static in vitro digestion method suitable for food – an international consensus
PublicationSimulated gastro-intestinal digestion is widely employed in many fields of food and nutritional sciences, as conducting human trials are often costly, resource intensive, and ethically disputable. As a consequence, in vitro alternatives that determine endpoints such as the bioaccessibility of nutrients and non-nutrients or the digestibility of macronutrients (e.g. lipids, proteins and carbohydrates) are used for screening and building...
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Static in vitro digestion model adapted to the general older adult population: an INFOGEST international consensus
PublicationUnderstanding the mechanisms of food digestion is of paramount importance to determine the effect foods have on human health. Significant knowledge on the fate of food during digestion has been generated in healthy adults due to the development of physiologically-relevant in vitro digestion models. However, it appears that the performance of the oro-gastrointestinal tract is affected by ageing and that a model simulating the digestive...
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Consequences of cathepsin C inactivation for membrane exposure of proteinase 3, the target antigen in autoimmune vasculitis
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INFOGEST static in vitro simulation of gastrointestinal food digestion
PublicationDeveloping a mechanistic understanding of the impact of food structure and composition on human health has increasingly involved simulating digestion in the upper gastrointestinal tract. These simulations have used a wide range of different conditions that often have very little physiological relevance, and this impedes the meaningful comparison of results. The standardized protocol presented here is based on an international consensus...
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DNA methylation as a mediator of HLA-DRB1*15:01 and a protective variant in multiple sclerosis
PublicationThe human leukocyte antigen (HLA) haplotype DRB1*15:01 is the major risk factor for multiple sclerosis (MS). Here, we find that DRB1*15:01 is hypomethylated and predominantly expressed in monocytes among carriers of DRB1*15:01. A differentially methylated region (DMR) encompassing HLA-DRB1 exon 2 is particularly affected and displays methylation-sensitive regulatory properties in vitro. Causal inference and Mendelian randomization...
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Assessing and Mitigating Ice-Jam Flood Hazards and Risks: A European Perspective
PublicationThe assessment and mapping of riverine flood hazards and risks is recognized by many countries as an important tool for characterizing floods and developing flood management plans. Often, however, these management plans give attention primarily to open-water floods, with ice-jam floods being mostly an afterthought once these plans have been drafted. In some Nordic regions, ice-jam floods can be more severe than open-water floods,...
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CCDC151 Mutations Cause Primary Ciliary Dyskinesia by Disruption of the Outer Dynein Arm Docking Complex Formation
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INFOGEST inter-laboratory recommendations for assaying gastric and pancreatic lipases activities prior to in vitro digestion studies
PublicationIn vitro digestion studies often use animal digestive enzyme extracts as substitutes of human gastric and pancreatic secretions. Pancreatin from porcine origin is thus commonly used to provide relevant pancreatic enzymes such as proteases, amylase and lipase. Rabbit gastric extracts (RGE) have been recently introduced to provide gastric lipase in addition to pepsin. Before preparing simulated gastric and pancreatic extracts with...
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ZMYND10 Is Mutated in Primary Ciliary Dyskinesia and Interacts with LRRC6
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Blind prediction of homo‐ and hetero‐protein complexes: The CASP13‐CAPRI experiment
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Comparability of Raman Spectroscopic Configurations: A Large Scale Cross-Laboratory Study
PublicationThe variable configuration of Raman spectroscopic platforms is one of the major obstacles in establishing Raman spectroscopy as a valuable physicochemical method within real-world scenarios such as clinical diagnostics. For such real world applications like diagnostic classification, the models should ideally be usable to predict data from different setups. Whether it is done by training a rugged model with data from many setups...
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The International Natural Product Sciences Taskforce (INPST) and the power of Twitter networking exemplified through #INPST hashtag analysis
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24/25 Seminarium dyplomowe
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SEMINARIUM DYPLOMOWE 23/24 - zima
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SEMINARIUM DYPLOMOWE 23/24 - lato
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A global multinational survey of cefotaxime-resistant coliforms in urban wastewater treatment plants
PublicationThe World Health Organization Global Action Plan recommends integrated surveillance programs as crucial strategies for monitoring antibiotic resistance. Although several national surveillance programs are in place for clinical and veterinary settings, no such schemes exist for monitoring antibiotic-resistant bacteria in the environment. In this transnational study, we developed, validated, and tested a low-cost surveillance and...
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Global 30-day outcomes after bariatric surgery during the COVID-19 pandemic (GENEVA): an international cohort study
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Clinical effectiveness of primary prevention implantable cardioverter-defibrillators: results of the EU-CERT-ICD controlled multicentre cohort study
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Going to extremes – a metagenomic journey into the dark matter of life
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Appropriate Shocks and Mortality in Patients With Versus Without Diabetes With Prophylactic Implantable Cardioverter Defibrillators
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10Kin1day: A Bottom-Up Neuroimaging Initiative
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10Kin1day: A bottom-up neuroimaging initiative
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Safety of Bariatric Surgery in ≥ 65-Year-Old Patients During the COVID-19 Pandemic
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30-Day Morbidity and Mortality of Bariatric Surgery During the COVID-19 Pandemic: a Multinational Cohort Study of 7704 Patients from 42 Countries
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Effect of BMI on safety of bariatric surgery during the COVID-19 pandemic, procedure choice, and safety protocols – An analysis from the GENEVA Study
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30-day morbidity and mortality of sleeve gastrectomy, Roux-en-Y gastric bypass and one anastomosis gastric bypass: a propensity score-matched analysis of the GENEVA data
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Prospective Observational Study on acute Appendicitis Worldwide (POSAW)
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Physiological parameters for Prognosis in Abdominal Sepsis (PIPAS) Study: a WSES observational study
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Handling of the Covid-19 Pandemic and Its Effects on Bariatric Surgical Practice: Analysis of GENEVA Study Database
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Considerations and consequences of allowing DNA sequence data as types of fungal taxa
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13th International Conference on Conservative Management of Spinal Deformities and First Joint Meeting of the International Research Society on Spinal Deformities and the Society on Scoliosis Orthopaedic and Rehabilitation Treatment – SOSORT-IRSSD 2016 meeting
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The ChoCO-W prospective observational global study: Does COVID-19 increase gangrenous cholecystitis?
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Elective surgery system strengthening: development, measurement, and validation of the surgical preparedness index across 1632 hospitals in 119 countries
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Global variation in anastomosis and end colostomy formation following left‐sided colorectal resection
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