Search
displaying 1000 best results Help
Search results for: Androgen receptor
-
Journal of the Bible and its Reception
Journals -
Dysfunctional prefrontal cortical network activity and interactions following cannabinoid receptor activation.
PublicationCoordinated activity spanning anatomically distributed neuronal networks underpins cognition and mediates limbic-cortical interactions during learning, memory, and decision-making. We used CP55940, a potent agonist of brain cannabinoid receptors known to disrupt coordinated activity in hippocampus, to investigate the roles of network oscillations during hippocampal and medial prefrontal cortical (mPFC) interactions in rats. During...
-
NK1 receptor binding of a few low molecular weight 3,5-bistrifluoromethylbenzene derivatives
Publication -
Structural Insights into σ1 Receptor Interactions with Opioid Ligands by Molecular Dynamics Simulations
Publication -
Fentanyl Family at the Mu-Opioid Receptor: Uniform Assessment of Binding and Computational Analysis
Publication -
Imidazo-thiazine, -diazinone and -diazepinone derivatives. Synthesis, structure and benzodiazepine receptor binding
Publication -
Molecular insights into receptor binding energetics and neutralization of SARS-CoV-2 variants
Publication -
Genetic Determinants of Vitamin D-Related Disorders; Focus on Vitamin D Receptor
Publication -
CRF1 receptor splicing in epidermal keratinocytes: Potential biological role and environmental regulations
Publication -
Hormonal Receptor Status Determines Prognostic Significance of FGFR2 in Invasive Breast Carcinoma
Publication -
Will we ever use angiotensin receptor neprilysin inhibition (ARNi) for the treatment of hypertension?
Publication -
In vivoevaluation of the CB1allosteric modulator LDK1258 reveals CB1-receptor independent behavioral effects
PublicationIn the present study, we examined whether LDK1258, which produces strong CB1receptor allosteric effects ininvitroassays, would elicitin vivoeffects consistent with allosteric activity. In initial studies, LDK1258 reducedfood consumption and elicited delayed antinociceptive effects in the chronic constrictive injury of the sciaticnerve (CCI) model of neuropathic pain, which unexpectedly emerged 4 h post-injection. UPLC-MS/MS analysisquantified...
-
new analogues of agmatine with higher activity to imidazoline receptors
PublicationOpracowano syntezę nowych pochodnych imidazoliny, będących kompilacją struktury agmatyny i imidazoliny w wyniku zaprojektowanej przez nas drogi syntezy. Kluczowymi substratami w syntezie były pochodne 1,2,4 -triaminobutanu, otrzymane z chronionego kwasu glutaminowego. Otrzymane nowe pochodne imidazoliny wykazywały zróżnicowane powinowactwo do receptorów imidazolinowych I1, I2 oraz do receptorów alfa -adrenergicznych.
-
Expression of hCG and GnRHs and Their Receptors in Endometrial Carcinoma and Hyperplasia
Publication -
Acceptor doping of barium cerate
Publication -
The electrochemical response to BDD electrode functionalization with CD147 receptor
Open Research DataThis dataset contains the results of the electrochemical impedance spectroscopy (EIS) measurements of the boron-doped diamond (BDD) electrode functionalization with CD147 receptor. The functionalized electrode was then used for the electrochemical detection of the SARS-CoV-2 virus S1 protein.
-
The electrochemical response to BDD electrode functionalization with ACE2 receptor
Open Research DataThis dataset contains the results of the electrochemical impedance spectroscopy (EIS) measurements of the boron-doped diamond (BDD) electrode functionalization with ACE2 receptor. The functionalized electrode was then used for the electrochemical detection of the SARS-CoV-2 virus S1 protein.
-
The electrochemical response to BDD electrode functionalization with IgG2B receptor
Open Research DataThis dataset contains the results of the electrochemical impedance spectroscopy (EIS) measurements of the boron-doped diamond (BDD) electrode functionalization with IgG2B receptor. The functionalized electrode was then used for the electrochemical detection of the SARS-CoV-2 virus S1 protein.
-
Structural studies on radiopharmaceutical DOTA-minigastrin analogue (CP04) complexes and their interaction with CCK2 receptor
Publication -
Novel Tools for Comprehensive Functional Analysis of LDLR (Low-Density Lipoprotein Receptor) Variants
PublicationFamilial hypercholesterolemia (FH) is an autosomal-dominant disorder caused mainly by substitutions in the low-density lipoprotein receptor (LDLR) gene, leading to an increased risk of premature cardiovascular diseases. Tremendous advances in sequencing techniques have resulted in the discovery of more than 3000 variants of the LDLR gene, but not all of them are clinically relevant. Therefore, functional studies of selected variants...
-
Coexpression of human chorionic gonadotropin beta subunit and its receptor in nontrophoblastic gynecological cancer
Publication -
Inhibition Ability of Natural Compounds on Receptor-Binding Domain of SARS-CoV2: An In Silico Approach
Publication -
Molecular Modeling of Interaction of the Vasopressin Analogs with Vasopressin and Oxytocin Receptors
Publication -
Neurotrophin serum concentrations and polymorphisms of neurotrophins and their receptors in children with asthma
Publication -
Chromogenic amides of pyridine-2,6-dicarboxylic acid as anion receptors
PublicationThe synthesis of simple, chromogenic pyridine-2,6-dicarboxylic acid amides, derivates of isomeric nitroanilines and aminonitrophenols, and their ion binding properties are described. The ligands' response to ionic species was examined by naked eye and was studied with the use of UV-Vis spectroscopy in DMSO and its mixture with water. The effect of the localisation and the type of the substituents in aromatic rings were discussed....
-
QSPR analysis of some agonists and antagonists of α-adrenergic receptors
Publication -
Estrogen receptors genes polymorphisms and age at menarche in idiopathic scoliosis
Publication -
Reception-Texts Readers Audiences History
Journals -
Low-dose radiation accelerates aging of the T-cell receptor repertoire in CBA/Ca mice
Publication -
Tricyclic xanthine derivatives containing a basic substituent: adenosine receptor affinity and drug-related properties
Publication -
Phenylalanine-Based AMPA Receptor Antagonist as the Anticonvulsant Agent with Neuroprotective Activity—In Vitro and In Vivo Studies
Publication -
Methodology of Selecting the Optimal Receptor to Create an Electrochemical Immunosensor for Equine Arteritis Virus Protein Detection
PublicationThe study reports a methodology of selecting the optimal receptor to create an electrochemical immunosensor for equine arteritis virus (EAV) protein detection. The detection was based on antigen recognition by antibodies immobilized on gold electrodes. Modification steps were controlled by electrochemical impedance spectroscopy and cyclic voltammetry measurements. In order to obtain the impedance immunosensor with the best parameters,...
-
Angiotensin receptor - neprilysin inhibiton (ARNI) – A novel therapeutic concept for management of hypertension and heart failure
Publication -
Methylation of estrogen receptor 2 (ESR2) in deep paravertebral muscles and its association with idiopathic scoliosis
Publication -
Methodology of Selecting the Optimal Receptor to Create an Electrochemical Immunosensor for Equine Arteritis Virus Protein Detection
PublicationThe study reports a methodology of selecting the optimal receptor to create an electrochemical immunosensor for equine arteritis virus (EAV) protein detection. The detection was based on antigen recognition by antibodies immobilized on gold electrodes. Modification steps were controlled by electrochemical impedance spectroscopy and cyclic voltammetry measurements. In order to obtain the impedance immunosensor with the best parameters,...
-
Molecular Dynamics Study of the Internal Water Molecules in Vasopressin and Oxytocin Receptors
Publication -
Estrogen receptors 1 and 2 genotypes and age at menarche in idiopathic scoliosis
Publication -
Recent Progress on Hydrogen Storage and Production Using Chemical Hydrogen Carriers
PublicationDepleting fossil fuel resources and anthropogenic climate changes are the reasons for the intensive development of new, sustainable technologies based on renewable energy sources. One of the most promising strategies is the utilization of hydrogen as an energy vector. However, the limiting issue for large-scale commercialization of hydrogen technologies is a safe, efficient, and economical method of gas storage. In industrial practice,...
-
Ryzykowna recepta na zarządzanie ryzykiem
PublicationCzy zaawansowana metodologia wyznaczania i alokacji kapitału ekonomicznego w bankach, wsparta przez odpowiednie normy regulacyjne, stanowi panaceum na bolączki związane z systemowymi ryzykami sektora bankowego? Idealizowanie tej recepty jest dość ryzykowne. Kapitał ekonomiczny to ciekawe narzędzie, ma ono jednak swoje niedoskonałości i pułapki.
-
Reception of GNSS Signals Under Jamming Conditions
PublicationThe article focuses on performance of Global Navigation Satellite System receivers in environment where intentional interference is present. First part is a general description of GNSS systems. Secondly, types of positioning service disturbances are specified. In the third part authors present a scheme of measurement stand which is used to evaluate the influence of interference on reception of navigation signals. Next, research...
-
Docking is not enough: 17-trifluoromethylphenyl trinor PGF2α is only a very weak ligand of neurokinin-1 receptor
Publication -
Correcting a widespread error: Neuroprotectant N-acetyl-L-tryptophan does not bind to the neurokinin-1 receptor
Publication -
Intrinsic effects of AM4113, a putative neutral CB1 receptor selective antagonist, on open-field behaviors in rats
PublicationW pracy przedstawiono wyniki testów otartego pola na zachowanie szczurów po iniekcji zwierzętom WIN55,21-2 (WIN; 3 mg/kg) agonisty receptora kanabinoidowego CB1R, bądź AM4113 (0.3−5.6 mg/kg) przypuszczalnie neutralnego antagonisty receptora kanabinoidowego CB1R oraz mieszaniny obu związków. W badaniach pod uwagę brano następujące zachowania zwierząt; ilość kwadratów, którą szczury przechodziły na czterech nogach, częstotliwość...
-
Phase 3 randomised study of avatrombopag, a novel thrombopoietin receptor agonist for the treatment of chronic immune thrombocytopenia
Publication -
Angiotensin receptor blockers and cancer – Relationship dismissed by VALUE data while waiting for EMA and FDA reports
Publication -
Ambulatory Blood Pressure Adds to Explaining Benefits of AT‐1 Receptor Blockade in the Treatment of Left Ventricular Hypertrophy
Publication -
Optimization of Chemical Functionalities of Indole-2-carboxamides To Improve Allosteric Parameters for the Cannabinoid Receptor 1 (CB1)
Publication5-Chloro-3-ethyl-N-(4-(piperidin-1-yl)phenethyl)-1H-indole-2-carboxamide (1; ORG27569) is a prototypical allosteric modulator for the cannabinoid type 1 receptor (CB1). Here, we reveal key structural requirements of indole-2-carboxamides for allosteric modulation of CB1: a critical chain length at the C3-position, an electron withdrawing group at the C5-position, the length of the linker between the amide bond and the phenyl ring...
-
Replication study of estrogen receptor 1 XbaI polymorphism in adolescent idiopathic scoliosis (AIS) Caucasian population
Publication -
Synthesis of Fentanyl Triazole Derivatives and their Affinity for Mu-Opioid and Sigma-1 Receptors
Publication -
Expression of estrogen receptors, PELP1, and SRC in human spermatozoa and their associations with semen quality
Publication