Search results for: MIKROSOMY

• Intensywność skażenia grafitu w żeliwie sferoidalnym niestopowym docieranym luźnym ścierniwem.

  Publication

  • A. Barylski

  - Journal of Machine Construction and Maintenance - Year 2002

  Przedstawiono wyniki badań skażenia powierzchni żeliwa sferoidalnego niestopowego docieranego luźnym ścierniwem. Ta wada docierania materiałów miękkich lub zawierających składniki o niskiej twardości ma istotne znaczenie zarówno ze względów technologicznych jak i eksperymentalnych. W przeprowadzonych eksperymentach skażenia grafitu wykorzystano mikroskopy skaningowe i mikroanalizę rentgenowską powierzchniową.

• Multimodal Audio-Visual Recognition of Traffic Events

  Publication

  • K. Łopatka
  • J. Kotus
  • M. Szczodrak
  • P. Marcinkowski
  • A. Korzeniewski
  • A. Czyżewski

  - Year 2011

  Przedstawiono demonstrator systemu wykrywania niebezpiecznych zdarzeń w ruchu drogowym oparty na jednoczesnej analizie danych wizyjnych i akustycznych. System jest częścią systemu automatycznego nadzoru bezpieczeństwa. Wykorzystuje on kamery i mikrofony jako źródła danych. Przedstawiono wykorzystane algorytmy - algorytmy rozpoznawania zdarzeń dźwiękowych oraz analizy obrazu. Zaprezentowano wyniki działania algorytmów na przykładzie...

• Metabolic transformation of antitumor agent C1311 with various fractions of rat liver.

  Publication

  • A. Wiśniewska
  • Z. Mazerska
  • J. Konopa

  - Year 2004

  Wykazano, że enzymatyczna aktywacja jest konieczna dla aktywności bilogicznej pochodnej C-1311. Zbadano przemiany związku w obecności różnych frakcji enzymatycznych mikrosomalnych komórek wątroby szczura.Badania te wykazały, że związek C-1311 jest bardziej podatny na transformację pod wpływem frakcji aktywowanych enzymów mikrosomalnych (CYP1A, CYP2B, CYP3A i CYP4A) niż frakcji S9, cytozolowej czy mikrosomów nieaktywowanych. Związek...

• Biotransformation of abused synthetic cannabinoids, JWH-018 and JWH-073, by human cytochromes P450 and UDP-glucuronosyltransferases

  Publication

  • A. Radominska-Pandya
  • K. C. Chimalakonda
  • S. M. Bratton
  • B. Fedejko-Kap
  • V. Le
  • K. H. Yiew
  • C. Moran
  • L. P. James
  • J. H. Moran

  - DRUG METABOLISM REVIEWS - Year 2011

  Związki oznaczone symbolami JWH-018 i JWH-073 są syntetycznymi pochodnymi kanabinoidów, obecnymi w preparatach o działaniu psychoaktywnym (K2/Spice). Wcześniejsze badań wykazały, że u osób przyjmujących tzw. ''legalną marihuanę'', głównymi produktami biotransformacji obecnymi w moczu były hydroksylowe pochodne obu związków, jak również ich glukuronidy. W związku z tym celem prowadzonych badań było określenie roli poszczególnych...

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• The role of intestine and liver in glucuronidation of the imidazo- and triazoloacridinone antitumor agents, C-1311 and C-1305: High affinity substrates for UGT1A10

  Publication

  • B. Fedejko-Kap
  • S. M. Bratton
  • M. Finel
  • Z. Mazerska
  • A. Radominska- Pandya

  - DRUG METABOLISM REVIEWS - Year 2011

  Celem przeprowadzonych badań było określenie roli poszczególnych izoform UDP-glukuronylotransferazy (UGT)oraz mikrosomów jelita(HIM)i wątroby (HLM) wyizolowanych od różnych pacjentów w metabolizmie pochodnych akrydonu, związków C-1311 i C-1305. Wykazano, że rodziną UGT katalizującą przemiany C-1305 i C-1311 jest UGT1A, z najwyższą aktywnością wykazywaną przez pozawątrobowy izoenzym UGT1A10. Rozkład aktywności frakcji mikrosomalnych...

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• KIDNEY, Kidney, NOS - Female, 0 - Tissue image [4130730018868801]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of KIDNEY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• KIDNEY, Kidney, NOS - Female, 0 - Tissue image [4130730018861601]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of KIDNEY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• COLON, Large bowel, NOS - Female, 0 - Tissue image [4130730018869201]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of COLON tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• ADRENAL GLAND, Adrenal gland, NOS - Female, 0 - Tissue image [413073001886751]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of ADRENAL GLAND tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• SMALL INTESTINE, Ileum - Female, 0 - Tissue image [4130730018868961]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of SMALL INTESTINE tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• BLADDER, Bladder wall, NOS - Female, 0 - Tissue image [4130730018865911]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BLADDER tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• HEMATOPOIETIC AND RETICULOENDOTHELIAL SYSTEMS, Spleen - Female, 0 - Tissue image [4130730018865011]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of HEMATOPOIETIC AND RETICULOENDOTHELIAL SYSTEMS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• LARYNX, Larynx, NOS - Female, 0 - Tissue image [4130730018868351]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of LARYNX tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• ZESTAW MIKROSKOPÓW 3 MIKROSKOPY SXIŁ ATOMOWYCH + MIKROSKOP TUNELOWY

  Research Equipment

  Faculty of Applied Physics and Mathematics

• Cerebral oedema - Female, 0 - Tissue image [4130730018863161]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BRAIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Cerebral oedema - Female, 0 - Tissue image [4130730018868141]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BRAIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Cerebral oedema - Female, 0 - Tissue image [4130730018865231]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BRAIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• TRACHEA, Trachea - Female, 0 - Tissue image [4130730018867831]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of TRACHEA tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Cerebral oedema - Female, 0 - Tissue image [4130730018868011]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BRAIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Cerebral oedema - Female, 0 - Tissue image [413073001886461]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BRAIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Atresia of oesophagus with tracheo-oesophageal fistula - Female, 0 - Tissue image [4130730018866031]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of TRACHEA tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Edwards' syndrome, unspecified - Female, 0 - Tissue image [4130730018866891]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of LIVER AND INTRAHEPATIC BILE DUCTS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Atresia of oesophagus with tracheo-oesophageal fistula - Female, 0 - Tissue image [4130730018861821]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of TRACHEA tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Cerebral oedema - Female, 0 - Tissue image [4130730018863341]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BRAIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Cerebral oedema - Female, 0 - Tissue image [4130730018862831]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BRAIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Edwards' syndrome, unspecified - Female, 0 - Tissue image [413073001886241]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of LIVER AND INTRAHEPATIC BILE DUCTS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Disease of pericardium, unspecified - Female, 0 - Tissue image [4130730018866061]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of HEART, MEDIASTINUM, AND PLEURA tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Ventricular septal defect - Female, 0 - Tissue image [4130730018866131]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of HEART, MEDIASTINUM, AND PLEURA tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Cerebral oedema - Female, 0 - Tissue image [4130730018861541]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BRAIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Edwards' syndrome, unspecified - Female, 0 - Tissue image [7040247104932801]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BRONCHUS AND LUNG tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Edwards' syndrome, unspecified - Female, 0 - Tissue image [4130730018865431]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BRONCHUS AND LUNG tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Edwards' syndrome, unspecified - Female, 0 - Tissue image [4130730018863211]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BRONCHUS AND LUNG tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Edwards' syndrome, unspecified - Female, 0 - Tissue image [4130730018863651]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BRONCHUS AND LUNG tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Electrochemical simulation of enzymatic transformations studied for the selected antitumor acridine derivatives

  Publication

  • A. Potęga
  • W. Hewelt-Belka
  • O. Siewruk
  • K. Zapała
  • Z. Mazerska

  - Year 2014

  The elucidation of the metabolic pathways and the biotransformation mechanisms of potential drugs is a crucial point in drug development. It allows to know the activation routes of the new biologically active compounds, especially in respect to their possible toxicity. Generally, in vivo or in vitro experiments with liver microsomes or hepatocytes are performed. However, these testing schemes are tedious, time consuming and of...

• Electrochemistry meets enzymes: Investigation of the biotransformation pathway of C-1311 based on electrochemical simulation in comparison to in vitro methods.

  Publication

  • A. Potęga

  - Journal 0f Clinical Toxicolgy - Year 2014

  The knowledge of the metabolic pathways and the biotransformation of new drugs is one of the major challenges in pharmaceutical research. It is crucial for elucidation of degradation routes of the new biologically active compounds, especially in the area of possible toxicity. Conventional in vitro drug metabolism studies are based on incubating drug candidate with e.g. hepatocytes or, most importantly, liver cell microsomes and...