Wyszukiwarka
Prof dr hab Adam Lesner
Zatrudnienie
- 1995 - present professor w Chemistry
Publikacje
Filtry
wszystkich: 116
Katalog Publikacji
Rok 2022
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Bile Acids: Key Players in Inflammatory Bowel Diseases?
Publikacja -
Theoretical Investigation of the Coronavirus SARS-CoV-2 (COVID-19) Infection Mechanism and Selectivity
Publikacja
Rok 2021
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Digestive Inflammation: Role of Proteolytic Dysregulation
Publikacja -
Elastolytic activity is associated with inflammation in bladder cancer
Publikacja -
Gut Serpinome: Emerging Evidence in IBD
Publikacja -
Lipidation of Temporin-1CEb Derivatives as a Tool for Activity Improvement, Pros and Cons of the Approach
Publikacja -
Non‐Proteasomal Urine Activity in Bladder Cancer
Publikacja -
Novel Cell Permeable Polymers of N-Substituted L-2,3-Diaminopropionic Acid (DAPEGs) and Cellular Consequences of Their Interactions with Nucleic Acids
Publikacja -
Proteinase release from activated neutrophils in mechanically ventilated patients with non-COVID-19 and COVID-19 pneumonia
Publikacja -
SP-1, a Serine Protease from the Gut Microbiota, Influences Colitis and Drives Intestinal Dysbiosis in Mice
Publikacja -
Structural Determinants of Substrate Specificity of SplF Protease from Staphylococcus aureus
Publikacja
Rok 2020
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A Peptidomimetic Fluorescent Probe to Detect the Trypsin β2 Subunit of the Human 20S Proteasome
Publikacja -
Activity-based protein profiling guided identification of urine proteinase 3 activity in subclinical rejection after renal transplantation
Publikacja -
Cathepsin C is a novel mediator of podocyte and renal injury induced by hyperglycemia
Publikacja -
Fecal Serine Protease Profiling in Inflammatory Bowel Diseases
Publikacja -
Human proteinase 3 resistance to inhibition extends to alpha‐2 macroglobulin
Publikacja -
Kallikrein 13 serves as a priming protease during infection by the human coronavirus HKU1
Publikacja -
Kallikrein-related peptidase 14 activates zymogens of membrane type matrix metalloproteinases (MT-MMPs) - a CleavEx library-based analysis
Publikacja -
Kallikrein-Related Peptidase 14 Activates Zymogens of Membrane Type Matrix Metalloproteinases (MT-MMPs)—A CleavEx Based Analysis
Publikacja -
Lung Protection by Cathepsin C Inhibition: A New Hope for COVID-19 and ARDS?
Publikacja -
Myeloperoxidase Modulates Inflammation in Generalized Pustular Psoriasis and Additional Rare Pustular Skin Diseases
Publikacja -
The molecular function of kallikrein‐related peptidase 14 demonstrates a key modulatory role in advanced prostate cancer
Publikacja
Rok 2019
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Aggregated neutrophil extracellular traps resolve inflammation by proteolysis of cytokines and chemokines and protection from antiproteases
Publikacja -
Development of Chemical Tools to Monitor Human Kallikrein 13 (KLK13) Activity
Publikacja -
Processing and Maturation of Cathepsin C Zymogen: A Biochemical and Molecular Modeling Analysis
Publikacja -
Properties of the HtrA Protease From Bacterium Helicobacter pylori Whose Activity Is Indispensable for Growth Under Stress Conditions
Publikacja -
Proteinase 3 phosphonic inhibitors
Publikacja -
Structure-based design and in vivo anti-arthritic activity evaluation of a potent dipeptidyl cyclopropyl nitrile inhibitor of cathepsin C
Publikacja -
The Bactericidal Activity of Temporin Analogues Against Methicillin Resistant Staphylococcus aureus
Publikacja
Rok 2018
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A Novel Biological Role for Peptidyl-Arginine Deiminases: Citrullination of Cathelicidin LL-37 Controls the Immunostimulatory Potential of Cell-Free DNA
Publikacja -
Biochemical properties of the HtrA homolog from bacterium Stenotrophomonas maltophilia
Publikacja -
Conjugate of Enkephalin and Temporin Peptides as a Novel Therapeutic Agent for Sepsis
Publikacja -
Consequences of cathepsin C inactivation for membrane exposure of proteinase 3, the target antigen in autoimmune vasculitis
Publikacja -
Design, Synthesis, and Enzymatic Evaluation of Novel ZnO Quantum Dot-Based Assay for Detection of Proteinase 3 Activity
PublikacjaHerein, the synthesis and application of functionalized quantum dot-based protease probes is described. Such probes are composed of nontoxic ZnO nanocrystals decorated by amino groups followed by linker and labeled peptide attachment. Spherical NH2-terminated ZnO quantum dots (QDs) with the average size ranging from 4 to 8 nm and strong emission centered at 530 nm were prepared using the sol−gel method. The fluorescence of ZnO...
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Exploiting the S4–S5 Specificity of Human Neutrophil Proteinase 3 to Improve the Potency of Peptidyl Di(chlorophenyl)-phosphonate Ester Inhibitors: A Kinetic and Molecular Modeling Analysis
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One Step Beyond: Design of Substrates Spanning Primed Positions of Zika Virus NS2B-NS3 Protease
Publikacja -
Therapeutic targeting of cathepsin C: from pathophysiology to treatment
Publikacja
Rok 2017
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Prolonged pharmacological inhibition of cathepsin C results in elimination of neutrophil serine proteases
Publikacja -
Selection of Effective HTRA3 Activators Using Combinatorial Chemistry
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Simplified, serine‐rich theta‐defensin analogues as antitumour peptides
Publikacja -
The role of the LB structural loop and its interactions with the PDZ domain of the human HtrA3 protease
Publikacja
Rok 2016
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Analysis of urinary cathepsin C for diagnosing Papillon–Lefèvre syndrome
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Antimicrobial peptides (AMPs) as drug candidates: a patent review (2003–2015)
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Bladder cancer detection using a peptide substrate of the 20S proteasome
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Development of the first internally-quenched fluorescent substrates of human cathepsin C: The application in the enzyme detection in biological samples
Publikacja -
Inhibitors and Antibody Fragments as Potential Anti-Inflammatory Therapeutics Targeting Neutrophil Proteinase 3 in Human Disease
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Intra- and intersubunit changes accompanying thermal activation of the HtrA2(Omi) protease homotrimer
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Lactoferrin Is an Allosteric Enhancer of the Proteolytic Activity of Cathepsin G
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Neutrophilic Cathepsin C Is Maturated by a Multistep Proteolytic Process and Secreted by Activated Cells during Inflammatory Lung Diseases
Publikacja -
Novel internally quenched substrate of the trypsin-like subunit of 20S eukaryotic proteasome
Publikacja
wyświetlono 1049 razy