Rok 2025

• Nanotechnology meets radiobiology: Fullerenols and Metallofullerenols as nano-shields in radiotherapy

  Publikacja

  • P. Kazmierska-grebowska,
  • M. Jankowski
  • E. Obrador
  • J. Kolodziejczyk-czepas
  • G. Litwinienko
  • J. Grebowski

  - BIOMEDICINE & PHARMACOTHERAPY - Rok 2025

  Despite significant advances in the development of radioprotective measures, the clinical application of radioprotectors and radiomitigators remains limited due to insufficient efficacy and high toxicity of most agents. Additionally, in oncological radiotherapy, these compounds may interfere with the therapeutic effectiveness. Recent progress in nanotechnology highlights fullerenols (FulOHs) and metallofullerenols (Me@FulOHs) as...

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Rok 2024

• Missing Puzzle Pieces in Dementia Research: HCN Channels and Theta Oscillations

  Publikacja

  • P. Kaźmierska-Grębowska
  • M. Jankowski
  • B. M. MacIver

  - Aging and Disease - Rok 2024

  Increasing evidence indicates a role of hyperpolarization activated cation (HCN) channels in controlling the resting membrane potential, pacemaker activity, memory formation, sleep, and arousal. Their disfunction may be associated with the development of epilepsy and age-related memory decline. Neuronal hyperexcitability involved in epileptogenesis and EEG desynchronization occur in the course of dementia in human Alzheimer’s Disease...

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• Revisiting serotonin’s role in spatial memory: A call for sensitive analytical approaches

  Publikacja

  • P. Kaźmierska-Grębowska
  • W. Żakowski
  • D. Myślińska
  • R. Sahu
  • M. Jankowski

  - INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY - Rok 2024

  The serotonergic system is involved in various psychiatric and neurological conditions, with serotonergic drugs often used in treatment. These conditions frequently affect spatial memory, which can serve as a model of declarative memory due to well-known cellular components and advanced methods that track neural activity and behavior with high temporal resolution. However, most findings on serotonin's effects on spatial learning...

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Rok 2023

• An automated, low-latency environment for studying the neural basis of behavior in freely moving rats

  Publikacja

  • M. Jankowski
  • A. Polterovich
  • A. Kazakov
  • J. Niediek
  • I. Nelken

  - BMC BIOLOGY - Rok 2023

  Background Behavior consists of the interaction between an organism and its environment, and is controlled by the brain. Brain activity varies at sub-second time scales, but behavioral measures are usually coarse (often consisting of only binary trial outcomes). Results To overcome this mismatch, we developed the Rat Interactive Foraging Facility (RIFF): a programmable interactive arena for freely moving rats with multiple feeding...

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