Rok 2023

• Unlocking the biosynthetic potential of Penicillium roqueforti for hyperproduction of the immunosuppressant mycophenolic acid: Gamma radiation mutagenesis and response surface optimization of fermentation medium

  Publikacja

  • E. El‐Sayed
  • A. Zaki
  • E. R. El-Sayed

  - BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY - Rok 2023

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Rok 2018

• Entrapment of DyP‐type peroxidase from Pseudomonas fluorescens Pf‐5 into Ca‐alginate magnetic beads

  Publikacja

  • A. Wasak
  • R. Drozd
  • Ł. Struk
  • B. Grygorcewicz

  - BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY - Rok 2018

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• Extracting functional groups of ALLINI to design derivatives of FDA‐approved drugs: Inhibition of HIV‐1 integrase

  Publikacja

  • U. Kalathiya
  • M. Padariya
  • M. Bagiński

  - BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY - Rok 2018

  HIV‐1 integrase (IN) is crucial for integration of viral DNA into the host genome and a promising target in development of antiretroviral inhibitors. In this work, six new compounds were designed by linking the structures of two different class of HIV‐1 IN inhibitors (active site binders and allosteric IN inhibitors (ALLINIs)). Among newly designed compounds, INRAT10b was found most potent HIV‐1 IN inhibitor considering different...

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• The psychrotrophic yeast Sporobolomyces roseus LOCK 1119 as a source of a highly active aspartic protease for the in vitro production of antioxidant peptides

  Publikacja

  • A. Białkowska
  • J. Krysiak
  • T. Florczak
  • K. Szulczewska
  • M. Wanarska
  • M. Turkiewicz

  - BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY - Rok 2018

  A psychrotrophic yeast strain producing a cold-adapted protease at low temperature was classified as Sporobolomyces roseus. In standard YPG medium, S. roseus LOCK 1119 synthesized an extracellular protease with an activity of approximately 560 U/L. Optimization of medium composition and process temperature considerably enhanced enzyme biosynthesis; an approximate 70% increase in activity (2060 U/L). The native enzyme was purified...

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Rok 2017

• Molecular basis and potential activity of HIV-1 reverse transcriptase toward trimethylamine-based compounds

  Publikacja

  • M. Padariya
  • U. Kalathiya
  • M. Bagiński

  - BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY - Rok 2017

  Reverse transcriptase (RT) inhibitors are currently used to treat human immunodeficiency virus (HIV)-1 infections. In this work, novel triethylamine derivatives were designed and studied by rigid and flexible docking and molecular dynamics (MD) approaches. An apo form of HIV-1 RT was also studied by MD simulation to analyze comparative response of protein in ligand-bound and ligand-unbound forms. Among newly designed HIV-1 RT inhibitors,...

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Rok 2016

• Identification of 1H‐indene‐(1, 3, 5, 6)‐tetrol derivatives as potent pancreatic lipase inhibitors using molecular docking and molecular dynamics approach

  Publikacja

  • U. Kalathiya
  • M. Padariya
  • M. Bagiński

  - BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY - Rok 2016

  Pancreatic lipase is a potential therapeutic target to treat diet-induced obesity in humans, as obesity-related diseases continue to be a global problem. Despite intensive research on finding potential inhibitors, very few compounds have been introduced to clinical studies. In this work, new chemical scaffold 1H-indene-(1,3,5,6)-tetrol was proposed using knowledge-based approach, and 36 inhibitors were derived by modifying its...

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Rok 2009

• Antibacterial and antioxidant activity of the secondary metabolites from in vitro cultures of alice sundew (drosera aliciae)

  Publikacja

  • A. Królicka
  • A. Szpitter
  • M. Maciąg
  • E. Biskup
  • E. Gilgenast-Krasińska
  • G. Gałęzowska (dawniej: G. Romanik)
  • M. A. Kamiński
  • G. Węgrzyniak
  • E. Łojkowska

  - BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY - Rok 2009

  Rośliny owadożerne (D. aliciae) produkują metabolity wtórne, farmakologicznie czynne substancje. Na wzrost akumulacji tychże substancji w tkankach roślin owadożernych ma wpływ dodatek elicytora. W pracy przedstawiono zarówno optymalizacje warunków hodowli roślin, jak również prawdopodobne mechanizmy działania bakteriobójczego. Końcowego oznaczenia zawartości metabolitów w ekstraktach roślinnych dokonano techniką chromatografii...