‘Acridines’ as New Horizons in Antifungal Treatment - Publikacja - MOST Wiedzy

Wyszukiwarka

‘Acridines’ as New Horizons in Antifungal Treatment

Abstrakt

Frequent fungal infections in immunocompromised patients and mortality due to invasive mycosis are important clinical problems. Opportunistic pathogenic Candida species remain one of the leading causes of systemic mycosis worldwide. The repertoire of antifungal chemotherapeutic agents is very limited. Although new antifungal drugs such as lanosterol 14α-demethylase and β-glucan synthase inhibitors have been introduced into clinical practice, the development of multidrug resistance has become increasingly significant. The urgency to expand the range of therapeutic options for the treatment of fungal infections has led researchers in recent decades to seek alternative antifungal targets to the conventional ones currently used. Among them, many compounds containing an acridine scaffold have been synthesized and tested. In this review, the applicability of acridines and their functional analogues acridones as antifungal agents is described. Acridine derivatives usage in photoantifungal chemotherapy, interactions with fungal transporters resulting in modulation of efflux/influx pumps and the effect of acridine derivatives on fungal topoisomerases are discussed. This article explores new perspectives on the mechanisms of antifungal acridine-peptide conjugates and acridine-based hybrid molecules to effectively combat fungal infections.

Cytowania

  • 6

    CrossRef

  • 6

    Web of Science

  • 6

    Scopus

Cytuj jako

Pełna treść

pobierz publikację
pobrano 9 razy
Wersja publikacji
Accepted albo Published Version
Licencja
Creative Commons: CC-BY otwiera się w nowej karcie

Słowa kluczowe

Informacje szczegółowe

Kategoria:
Publikacja w czasopiśmie
Typ:
artykuły w czasopismach
Opublikowano w:
MOLECULES nr 25,
ISSN: 1420-3049
Język:
angielski
Rok wydania:
2020
Opis bibliograficzny:
Gabriel I.: ‘Acridines’ as New Horizons in Antifungal Treatment// MOLECULES -Vol. 25,iss. 7 (2020), s.1480-
DOI:
Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.3390/molecules25071480
Weryfikacja:
Politechnika Gdańska

wyświetlono 47 razy

Publikacje, które mogą cię zainteresować

Meta Tagi