Analytical procedures for quality control of pharmaceuticals in terms of residual solvents content: Challenges and recent developments - Publikacja - MOST Wiedzy

Wyszukiwarka

Analytical procedures for quality control of pharmaceuticals in terms of residual solvents content: Challenges and recent developments

Abstrakt

Residual solvents play an important role in the synthesis of drugs and in product formulations. In addition, they pose a serious problem, that is toxicity, as many of them exhibit toxic or environmentally hazardous properties. Therefore, constant monitoring of quality control is needed. In this study, we present an overview of regulatory and general methods described by various pharmacopoeias. Then, the most commonly used methodologies for the determination of residual solvents in different pharmaceutical samples are reviewed to demonstrate their limitations, which form the basis of discussion about new methods. Several interesting new alternatives for sample preparation and gas chromatography (GC) separation are presented using examples from recent studies. The techniques described are direct injection, headspace analysis with different modifications and variations, liquid extraction, single-drop microextraction, and solid-phase microextraction. Various GC separation techniques are compared and new solutions to improve sensitivity and efficiency are presented.

Cytowania

  • 2 4

    CrossRef

  • 2 8

    Web of Science

  • 2 5

    Scopus

Autorzy (3)

Cytuj jako

Pełna treść

pełna treść publikacji nie jest dostępna w portalu

Słowa kluczowe

Informacje szczegółowe

Kategoria:
Publikacja w czasopiśmie
Typ:
artykuł w czasopiśmie wyróżnionym w JCR
Opublikowano w:
TRAC-TRENDS IN ANALYTICAL CHEMISTRY nr 80, strony 328 - 344,
ISSN: 0165-9936
Język:
angielski
Rok wydania:
2016
Opis bibliograficzny:
Tankiewicz M., Namieśnik J., Sawicki W.: Analytical procedures for quality control of pharmaceuticals in terms of residual solvents content: Challenges and recent developments// TRAC-TRENDS IN ANALYTICAL CHEMISTRY. -Vol. 80, (2016), s.328-344
DOI:
Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.1016/j.trac.2015.09.008
Weryfikacja:
Politechnika Gdańska

wyświetlono 56 razy

Publikacje, które mogą cię zainteresować

Meta Tagi