Abstrakt

Doctoral dissertation is divided into three main parts: introduction, results and discussion and experimental. The introduction is divided into four main parts which describe: 5-hydroxytryptamine receptors, the most popular antidepressants, new compounds based on the carbazole structure with affinity for serotonin receptors, telomeres and telomerase with their functions, telomerase inhibition strategies, carbazoles approved in cancer treatment, new carbazole derivatives which are telomerase inhibitors and selected methods of synthesis tetrahydrocarbazole and carbazole derivatives. The main part of the work are results and discussion. In this chapter the effects of experiments in the synthesis of 1,2,3,4-tetrahydrocyclopenta[b]indoles, 1,2,4-trisubstituted carbazole derivatives and 1,2,3,6-tetrasubstituted carbazole derivatives are described. The experimental part includes procedures for the preparation of compounds, spectral analysis of products and a list of instruments that were used in the implementation of this work.

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