New Biocompatible Ti-MOF@hydroxyapatite Composite Boosted with Gentamicin for Postoperative Infection Control - Publikacja - MOST Wiedzy

Twoje konto

zaloguj

Wyszukiwarka

New Biocompatible Ti-MOF@hydroxyapatite Composite Boosted with Gentamicin for Postoperative Infection Control

Abstrakt

The standard clinical management of osteomyelitis involves prolonged antibiotic therapy, which frequently necessitates the excision of infected tissues. However, the efficacy of such treatments is increasingly compromised by the rise of antibiotic-resistant pathogens, underscoring an urgent need for innovative approaches. This study introduces a novel composite material designed to offer dual functionality: robust antimicrobial activity and promotion of bone regeneration. The composite integrates biocompatible hydroxyapatite nanoparticles (HA) with a titanium(IV)–metal–organic framework, MIL-125(Ti)-NH2, impregnated with gentamicin (GM). The solvothermally synthesized MIL-125-NH2@HA composite demonstrates high cytocompatibility, as evidenced by assays using osteoblasts (U2-OS) and fibroblasts (L929), alongside an absence of hemolytic activity at concentrations of up to 1000 μg/mL. Importantly, the introduction of GM into the composite significantly amplifies its antibacterial efficacy against Staphylococcus aureus and Pseudomonas aeruginosa. Additionally, nanoindentation assessments reveal enhanced mechanical properties of the MIL-125-NH2@HA composite, indicating the superior elastic performance relative to unmodified HA. The findings of this research are poised to generate significant interest in the development of metal–organic framework (MOF)-based composites for antimicrobial implant applications, presenting a promising avenue for addressing the challenges posed by antibiotic resistance in bone infections.

Cytowania

  • 0

    CrossRef

  • 0

    Web of Science

  • 0

    Scopus

Autorzy (9)

Cytuj jako

Pełna treść

pełna treść publikacji nie jest dostępna w portalu

Słowa kluczowe

Informacje szczegółowe

Kategoria:
Publikacja w czasopiśmie
Typ:
artykuły w czasopismach
Opublikowano w:
ACS Biomaterials Science & Engineering nr 10, strony 7555 - 7565,
ISSN: 2373-9878
Język:
angielski
Rok wydania:
2024
Opis bibliograficzny:
Bodylska W., Junka A., Brożyna M., Bartmański M., Gadzała-Kopciuch R., Jaromin A., Navarro J. A. R., Lukowiak A., Fandzloch M.: New Biocompatible Ti-MOF@hydroxyapatite Composite Boosted with Gentamicin for Postoperative Infection Control// ACS Biomaterials Science & Engineering -,iss. 12 (2024), s.7555-7565
DOI:
Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.1021/acsbiomaterials.4c01230
Źródła finansowania:
  • Publikacja bezkosztowa
Weryfikacja:
Politechnika Gdańska

wyświetlono 1 razy

Publikacje, które mogą cię zainteresować

Bovine Serum Albumin – Hydroxyapatite Nanoflowers as Potential Local Drug Delivery System of Ciprofloxacin

  • K. Bobrowska,
  • K. Sadowska,
  • K. Stolarczyk
  • + 3 autorów
2023

Cu-HKUST-1 and Hydroxyapatite–The Interface of Two Worlds toward the Design of Functional Materials Dedicated to Bone Tissue Regeneration

  • M. Fandzloch,
  • W. Bodylska,
  • J. Trzcińska-Wencel
  • + 6 autorów
2023

Titania Nanotubes/Hydroxyapatite Nanocomposites Produced with the Use of the Atomic Layer Deposition Technique: Estimation of Bioactivity and Nanomechanical Properties

  • A. Radtke,
  • M. Ehlert,
  • T. Jędrzejewski
  • + 8 autorów
2019

Mission impossible for cellular internalization: When porphyrin alliance with UiO-66-NH2 MOF gives the cell lines a ride

  • S. Ahmadi,
  • V. Jajarmi,
  • M. Ashrafizadeh
  • + 6 autorów
2022
Meta Tagi