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• 5-Thiocyanato-2′-deoxyuridine as a possible radiosensitizer: electron-induced formation of uracil-C5-thiyl radical and its dimerization

  Publikacja

  • M. Zdrowowicz
  • L. Chomicz
  • M. Żyndul
  • P. Wityk
  • J. Rak
  • T. Wiegand
  • C. Hanson
  • A. Adhikary
  • M. Sevilla

  - PHYSICAL CHEMISTRY CHEMICAL PHYSICS - Rok 2015

  In this work, we have synthesized 5-thiocyanato-2′-deoxyuridine (SCNdU) along with the C6-deuterated nucleobase 5-thiocyanatouracil (6-D-SCNU) and studied their reactions with radiation-produced electrons. ESR spectra in γ-irradiated nitrogen-saturated frozen homogeneous solutions (7.5 M LiCl in H2O or D2O) of these compounds show that electron-induced S–CN bond cleavage occurs to form a thiyl radical (dU-5-S˙ or 6-D-U-5-S˙) and...

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• Intramolecular Proton Transfer in the Radical Anion of Cytidine Monophosphate Sheds Light on the Sensitivities of Dry vs Wet DNA to Electron Attachment-Induced Damage

  Publikacja

  • L. Chomicz-Mańka
  • A. Czaja
  • K. Falkiewicz
  • M. Zdrowowicz
  • K. Biernacki
  • S. Demkowicz
  • F. Izadi
  • E. Arthur-Baidoo
  • S. Denifl
  • Z. Zhu... i 4 innych

  - JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Rok 2023

  Single-strand breaks (SSBs) induced via electron attachment were previously observed in dry DNA under ultrahigh vacuum (UHV), while hydrated electrons were found not able to induce this DNA damage in an aqueous solution. To explain these findings, crossed electron-molecular beam (CEMB) and anion photoelectron spectroscopy (aPES) experiments coupled to density functional theory (DFT) modeling were used to demonstrate the fundamental...

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