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• Targeting of FLT3-ITD kinase contributes to high selectivity of imidazoacridinone C-1311 against FLT3-activated leukemia cells

  Publikacja

  • A. Skwarska
  • E. Augustin
  • M. Beffinger
  • A. Wojtczyk
  • S. Konicz
  • K. Laskowska
  • J. Polewska

  - BIOCHEMICAL PHARMACOLOGY - Rok 2015

  Drugs targeting receptor tyrosine kinase FLT3 are of particular interest since activating FLT3-internal tandem duplication (ITD) mutations abundantly occur in fatal acute myeloid leukemias (AMLs). Imidazoacridinone C-1311, a DNA-reactive inhibitor of topoisomerase II, has been previously shown to be a potent and selective inhibitor of recombinant FLT3. Here, we expand those findings by studying its effect on leukemia cells with...

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• Aravind Ayyolath

  Osoby

  I am interested in the biology of bacterial stress response and its growth under stress conditions. Our lab focuses on two aspects; protein folding and lipopolysaccharide biosynthesis and we address them with Escherichia coli models. Our recent studies have provided more evidence regarding several genes involved in the survival of bacteria under stress. I am also interested in disease biology and also in identifying proper therapeutic...

• Architektura a dekonstrukcja. Przypadek Petera Eisenmana i Bernarda Tschumiego

  Publikacja

  • C. Wąs

  - Rok 2015

  Architecture and Deconstruction Case of Peter Eisenman and Bernard Tschumi   Introduction Towards deconstruction in architecture Intensive relations between philosophical deconstruction and architecture, which were present in the late 1980s and early 1990s, belong to the past and therefore may be described from a greater than...

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