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• Structural, functional, and stability change predictions in human telomerase upon specific point mutations,

  Publikacja

  • U. Kalathiya
  • M. Padariya
  • M. Bagiński

  - Scientific Reports - Rok 2019

  Overexpression of telomerase is one of the hallmarks of human cancer. Telomerase is important for maintaining the integrity of the ends of chromosomes, which are called telomeres. A growing number of human disease syndromes are associated with organ failure caused by mutations in telomerase (hTERT or hTR). Mutations in telomerase lead to telomere shortening by decreasing the stability of the telomerase complex, reducing its accumulation,...

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