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• Synthesis and antiproliferative activity of new mycophenolic acid conjugates with adenosine derivatives

  Publikacja

  • M. Prejs
  • G. Cholewiński
  • P. Trzonkowski
  • A. Kot-Wasik
  • K. Dzierzbicka

  - JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH - Rok 2019

  New conjugates of mycophenolic acid (MPA) and adenosine derivatives were synthesized and assessed as potential immunosuppressants on Jurkat cell line and peripheral blood mononuclear cells (PBMC) from healthy donors. As compared to MPA, all compounds were found to be more active against Jurkat cell line. The antiproliferative activities were compared with MPA and adenosine, in both 2′,3′-O-isopropylidene protected and free hydroxyl...

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