Wyniki wyszukiwania dla: HISTONE DEACETYLASES

• HDAC Inhibitors: Innovative Strategies for Their Design and Applications

  Publikacja

  • M. Daśko
  • B. De Pascual-Teresa
  • I. Ortín
  • A. Ramos

  - MOLECULES - Rok 2022

  Histone deacetylases (HDACs) are a large family of epigenetic metalloenzymes that are involved in gene transcription and regulation, cell proliferation, differentiation, migration, and death, as well as angiogenesis. Particularly, disorders of the HDACs expression are linked to the development of many types of cancer and neurodegenerative diseases, making them interesting molecular targets for the design of new efficient drugs...

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• Chemical Aspects of Biological Activity of Isothiocyanates and Indoles, the Products of Glucosinolate Decomposition

  Publikacja

  • D. Kołodziejski
  • I. Koss-Mikołajczyk
  • A. Y. Abdin
  • J. Claus
  • A. Bartoszek-Pączkowska

  - CURRENT PHARMACEUTICAL DESIGN - Rok 2019

  There is growing evidence that cancer chemoprevention employing natural, bioactive compounds may halt or at least slow down the different stages of carcinogenesis. A particularly advantageous effect is attributed to derivatives of sulfur-organic phytochemicals, such as glucosinolates (GLs) synthesized mainly in Brassicaceae plant family. GLs are hydrolysed enzymatically to bioactive isothiocyanates (ITC) and indoles, which exhibit strong...

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