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• Phenotypic consequences of the LYS4 gene disruption in Candida albicans

  Publikacja

  • I. Gabriel
  • K. Kur
  • A. Mazur
  • B. Hube
  • S. Milewski

  - MYCOSES - Rok 2012

  The main scientific purpose of our studies was to verify the hypothesis that homoaconitase (HA) from Candida albicans, an enzyme catalyzing a second step of the α-aminoadipate pathway (AAP) of L-Lys biosynthesis may become a new target for antifungal chemotherapy. Previous studies indicated that the A. fumigatus mutant lacking the functional lysF gene, encoding HA, exhibited attenuated virulence in a low-dose mouse infection model...

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