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• Peptide Permeases in Candida albicans

  Publikacja

  • M. Schielmann
  • J. MORSCHHäUSER
  • S. Milewski

  - MYCOSES - Rok 2012

  Aims: The aim of this work was to characterize oligopeptide uptake in Candida albicans mutants in which the genes encoding putative peptide permeases were selectively disrupted. Initial velocities of transport of model oligopeptides, (Ala)2, (Ala)3, (Ala)4, and sensitivity of mutants to antifungal oligopeptides containing N3-(4-methoxyfumaroyl)-L-2,3-diaminopropanoic acid (FMDP) were determined and compared to those of the wild-type...

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• Transport deficiency is the molecular basis of Candida albicans resistance to antifungal oligopeptides

  Publikacja

  • M. Schielmann
  • P. Szweda
  • K. M. Gucwa
  • M. Kawczyński
  • M. J. Milewska
  • D. Martynow
  • J. Morschhauser
  • S. Milewski

  - Frontiers in Microbiology - Rok 2017

  (FMDP), an inhibitor of glucosamine-6-phosphate synthase, exhibited growth inhibitory activity against Candida albicans, with minimal inhibitory concentration values in the 0.05–50 mg/L range. Uptake by the peptide permeases was found to be the main factor limiting an anticandidal activity of these compounds. Di- and tripeptide containing FMDP (F2 and F3) were transported by Ptr2p/Ptr22p peptide transporters (PTR) and FMDP-containing...

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