Wyniki wyszukiwania dla: TRANSPORTAN

• Dual-Activity Fluoroquinolone-Transportan 10 Conjugates offer alternative Leukemia therapy during Hematopoietic Cell Transplantation

  Publikacja

  • J. Lica
  • M. Heldt
  • M. Wieczór
  • P. Chodnicki
  • N. Ptaszyńska
  • A. Łęgowska
  • W. Brankiewicz
  • K. Gucwa
  • A. Stupak
  • N. Maciejewska... i 8 innych

  - MOLECULAR PHARMACOLOGY - Rok 2024

  Hematopoietic cell transplantation (HCT) is often considered a last resort leukemia treatment, fraught with limited success due to microbial infections, a leading cause of mortality in leukemia patients. To address this critical issue, we explored a novel approach by synthesizing antileukemic agents containing antibacterial substances. This innovative strategy involves conjugating fluoroquinolone antibiotics, such as ciprofloxacin...

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• Conjugates of Ciprofloxacin and Levofloxacin with Cell-Penetrating Peptide Exhibit Antifungal Activity and Mammalian Cytotoxicity

  Publikacja

  • N. Ptaszyńska
  • K. Gucwa
  • K. Olkiewicz
  • M. Heldt
  • M. Serocki
  • A. Stupak
  • D. Martynow
  • D. Dębowski
  • A. Gitlin-Domagalska
  • J. Lica... i 3 innych

  - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES - Rok 2020

  Seven conjugates composed of well-known fluoroquinolone antibacterial agents, ciprofloxacin (CIP) or levofloxacin (LVX), and a cell-penetrating peptide transportan 10 (TP10-NH2) were synthesised. The drugs were covalently bound to the peptide via an amide bond, methylenecarbonyl moiety, or a disulfide bridge. Conjugation of fluoroquinolones to TP10-NH2 resulted in congeners demonstrating antifungal in vitro activity against human...

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