Wyniki wyszukiwania dla: computational biology
-
PLoS Computational Biology
Czasopisma -
Biomedical Engineering and Computational Biology
Czasopisma -
International Journal of Computational Biology
Czasopisma -
Journal of Bioinformatics and Computational Biology
Czasopisma -
COMPUTATIONAL BIOLOGY AND CHEMISTRY
Czasopisma -
JOURNAL OF COMPUTATIONAL BIOLOGY
Czasopisma -
International Journal of Computational Biology and Drug Design
Czasopisma -
IEEE-ACM Transactions on Computational Biology and Bioinformatics
Czasopisma -
International Journal for Computational Biology
Czasopisma -
European Conference on Computational Biology
Konferencje -
IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology
Konferencje -
International Conference on Practical Applications of Computational Biology & Bioinformatics
Konferencje -
International Conference on Computational Molecular Biology
Konferencje -
Generalization of Phylogenetic Matching Metrics with Experimental Tests of Practical Advantages
PublikacjaThe ability to quantify a dissimilarity of different phylogenetic trees is required in various types of phylogenetic studies, for example, such metrics are used to assess the quality of phylogeny construction methods and to define optimization criteria in supertree building algorithms. In this article, starting from the already described concept of matching metrics, we define three new metrics for rooted phylogenetic trees. One...
-
Personalized prediction of the secondary oocytes number after ovarian stimulation: A machine learning model based on clinical and genetic data
PublikacjaControlled ovarian stimulation is tailored to the patient based on clinical parameters but estimating the number of retrieved metaphase II (MII) oocytes is a challenge. Here, we have developed a model that takes advantage of the patient’s genetic and clinical characteristics simultaneously for predicting the stimulation outcome. Sequence variants in reproduction-related genes identified by next-generation sequencing were matched...
-
CAVER 3.0: A Tool for the Analysis of Transport Pathways in Dynamic Protein Structures
Publikacja -
Kinetic flux vector splitting scheme for solving non-reactive multi-component flows
Publikacja -
Structure-based design and evaluation of novel N-phenyl-1H-indol-2-amine derivatives for fat mass and obesity-associated (FTO) protein inhibition
PublikacjaFat mass and obesity-associated (FTO) protein contributes to non-syndromic human obesity which refers to excessive fat accumulation in human body and results in health risk. FTO protein has become a promising target for anti-obesity medicines as there is an immense need for the rational design of potent inhibitors to treat obesity. In our study, a new scaffold N-phenyl-1H-indol-2-amine was selected as a base for FTO protein inhibitors...
-
Comparing Phylogenetic Trees by Matching Nodes Using the Transfer Distance Between Partitions
PublikacjaAbility to quantify dissimilarity of different phylogenetic trees describing the relationship between the same group of taxa is required in various types of phylogenetic studies. For example, such metrics are used to assess the quality of phylogeny construction methods, to define optimization criteria in supertree building algorithms, or to find horizontal gene transfer (HGT) events. Among the set of metrics described so far in...
-
Two-step mechanism of J-domain action in driving Hsp70 function
PublikacjaJ-domain proteins (JDPs), obligatory Hsp70 cochaperones, play critical roles in protein homeostasis. They promote key allosteric transitions that stabilize Hsp70 interaction with substrate polypeptides upon hydrolysis of its bound ATP. Although a recent crystal structure revealed the physical mode of interaction between a J-domain and an Hsp70, the structural and dynamic consequences of J-domain action once bound and how Hsp70s...