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• In vitro enzyme kinetics and NMR-based product elucidation for glutathione S-conjugation of the anticancer unsymmetrical bisacridine C-2028 in liver microsomes and cytosol: major role of glutathione S-transferase M1-1 isoenzyme

  Publikacja

  • A. Potęga
  • D. Rafalska
  • D. Kazimierczyk
  • M. Kosno
  • A. Pawłowicz
  • W. Andrałojć
  • E. Paluszkiewicz
  • T. Laskowski

  - MOLECULES - Rok 2023

  This work is the next step in studying the interplay between C-2028 (anticancer-active unsymmetrical bisacridine developed in our group) and the glutathione S-transferase/glutathione (GST/GSH) system. Here, we analyzed the concentration- and pH-dependent GSH conjugation of C-2028 in rat liver microsomes and cytosol. We also applied three recombinant human GST isoenzymes, which altered expression was found in various tumors. The...

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