Wyniki wyszukiwania dla: steroid estrogens

• Recent progress in the development of steroid sulfatase inhibitors – examples of the novel and most promising compounds from the last decade

  Publikacja

  • M. Daśko
  • S. Demkowicz
  • K. Biernacki
  • O. Ciupak
  • W. Kozak
  • M. Masłyk
  • J. Rachoń

  - JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY - Rok 2020

  The purpose of this review article is to provide an overview of recent achievements in the synthesis of novel steroid sulfatase (STS) inhibitors. STS is a crucial enzyme in the biosynthesis of active hormones (including estrogens and androgens) and, therefore, represents an extremely attractive molecular target for the development of hormone-dependent cancer therapies. The inhibition of STS may effectively reduce the availability...

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• The PolarScreen™ Estrogen Receptor Competitor Assays for determination of estradiol equivalent concentrations (EEQs) in sewage and drinking water samples.

  Dane Badawcze

  open access

  • K. Kozłowska-Tylingo
  • M. Wanarska

  Municipal waste waters are one of the main sources of estrogenic compounds in aquatic environments. Feminization of fish downstream of Waste Water Treatment Plants (WWTPs) discharges has been observed worldwide. Some estrogenic chemicals, particularly steroid estrogens, are known to cause disruption of the endocrine system of fishes and abnormalities...